Included in the formulation
АТХ:V.04.C.J. Tests for the determination of thyroid function
V.04.C.J.02 Protirelin
Pharmacodynamics:Synthetic analogue of thyrotropin-releasing hormone of the hypothalamus. Promotes the release of thyroid-stimulating hormone (TTG) in the anterior pituitary gland and increases the concentration of prolactin.The stimulation of TSH secreted by the protyrelin is blocked by thyroxine and potentiated by its absence, so that the response of TSH to the administration of protyrelin is a diagnostic criterion when using the drug for diagnostic purposes to detect hyperthyroid and hypothyroid conditions. The ability to increase the concentration of prolactin allow to apply the drug in diagnosis in women with hypo- and agalactia, as it makes it possible to determine the pituitary reserve of prolactin. An increase in the content of these hormones in the blood serum is noted 1-2 min after intravenous administration. The peak of stimulated concentration of TSH is observed after 20-30 minutes and returns to the initial level in 2-3 hours.
Pharmacokinetics:After intravenous administration, the elimination half-life is 5 minutes.
Indications:Diagnosis of pituitary insufficiency in patients with hypothyroid conditions, diagnosis of hypo- and agalactia in women.
IV Diseases of the endocrine system, eating disorders and metabolic disorders
Contraindications:Hypersensitivity, organic lesions of the central nervous system, epilepsy, acute period of myocardial infarction, unstable angina, predisposition to bronchoobstructive syndrome, pregnancy.
Carefully:Arrhythmias, labile arterial hypertension, stable stenocardia, tumors of the pituitary gland, predisposition to bronchial obstructive syndrome, lactation period.
Pregnancy and lactation:Contraindicated in pregnancy. There is no information on the penetration into breast milk.
Dosing and Administration:Adults: intravenously slowly 500 mcg. The concentration of TSH is measured before and 30 minutes after the injection.
For children: 7 μg / kg (up to 500 μg). Time and frequency of measurement of TSH concentration are the same as in adults.
Side effects:AD fluctuations, headache, blindness, photophobia, anxiety, sweating, a sensation of a coma in the throat, a feeling of contraction in the chest, apoplexy of the pituitary gland, abdominal pain, xerostomia, unpleasant taste in the mouth, allergic reactions; redness and tenderness at the injection site.
Overdose:Increased severity of side effects.Treatment symptomatic.
Special instructions:No data