Antithrombin III (Antithrombinum III)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Anticoagulants

Included in the formulation
  • Antithrombin III human
    lyophilizate d / infusion 
    Baxter AG     Austria
    • Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):

    ONLS

    АТХ:

    B.01.A   Anticoagulants

    Pharmacodynamics:

    Anticoagulant direct action, inhibits thrombin, potentiates the effects of heparin.

    Has anticoagulant and antithrombotic effects.

    Pharmacokinetics:

    Half-life is 1-2 days. It is shortened with simultaneous exposure to heparin, with the syndrome disseminated intravascular coagulation and after surgical interventions.


    Indications:

    It is used to treat and prevent thromboembolic complications, with consumption coagulopathy, hemodialysis operations, pre-eclampsia.

    ICD-10

    III.D65-D69.D65   Disseminated intravascular coagulation [defibrillation syndrome]

    IX.I80-I89.I82.8   Embolism and thrombosis of other specified veins

    IX.I70-I79.I74   Embolism and thrombosis of the arteries

    Contraindications:

    Presence in the anamnesis of heparin-induced thrombocytopenia.

    Individual intolerance.

    Carefully:

    Pregnancy. The drug is prescribed in cases of emergency.

    Pregnancy and lactation:

    Pregnancy and lactation: recommendations for Food and Drug Administration (US Food and Drug Administration) - B. It is assumed that, due to the large size of the drug molecule, penetration into breast milk is excluded.

    Dosing and Administration:

    Intravenously with an initial dose of 1000-2000 IU, then 2000-3000 IU per day by prolonged infusion, or bolus - every 4 hours at 500 IU.

    Prophylactic dose: 1000-1500 IU per day.

    The highest daily dose: 3000 IU.

    The highest single dose: 500 IU.

    Side effects:

    Hypotension or hypertension, dyspnea, chest pain, increased diuresis.

    Allergic reactions.

    Overdose:

    Cases of overdose are not described.

    Interaction:

    Potentiates the action of heparin. In order to prevent bleeding with the simultaneous administration of drugs should reduce the dose of heparin to 500 IU.

    Special instructions:

    When administering the drug, it is recommended to monitor the content of antithrombin III in the blood: at the beginning of treatment - 2 times in the first day, then - daily.

    The drug should not be mixed with other medication.

    Instructions
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