Rifaximin - instructions for use, doses, side effects, contraindications

Clinical and pharmacological group: & nbsp

Ansamycins

Included in the formulation

Alpha normix®

pills inwards

Alfa Wassermann SpA Italy

Alpha normix®

granules inwards

Alfa Wassermann SpA Italy

АТХ:

A.07.A.A Antibiotics

A.07.A.A.11 Rifaximin

Pharmacodynamics:

The broad-spectrum antibiotic is a semisynthetic derivative of rifamycin SV. Irreversibly binds the beta subunits of the enzyme of bacteria, DNA-dependent RNA polymerase and, consequently, inhibits the synthesis of RNA and bacterial proteins. As a result of irreversible binding to the enzyme, rifaximin exhibits bactericidal properties against sensitive bacteria.

It has a wide spectrum of antibacterial activity, including most gram-negative and gram-positive, aerobic and anaerobic bacteria that cause gastrointestinal infections, including travelers' diarrhea.

Active against gram-negative aerobic bacteria: Salmonella spp, Shigella spp, enteropathogenic strains of Escherichia coli, Proteus spp, Campylobacter spp, Pseudomonas spp, Yersinia spp, Enterobacter spp, Klebsiella spp, Helicobacter pylori;........ Gram-negative anaerobes: Bacteroides spp., including Bacteroides fragilis, Fusobacterium nucleatum; Gram-positive aerobes: Streptococcus spp, Enterococcus spp, including Enterococcus fecalis, Staphylococcus spp .;.. Gram-positive anaerobes: Clostridium spp., including Clostridium difficile and Clostridium perfrigens, Peptostreptococcus spp. It acts in the lumen of the intestine.

Pharmacokinetics:

Absorption is insignificant (<1%). Biotransformation is absent. Elimination almost entirely with feces, kidneys 0.32%.

Indications:

Treatment of gastrointestinal infections caused by bacteria that are sensitive to rifaximin, including acute gastrointestinal infections; travelers diarrhea; syndrome of excessive growth of microorganisms in the intestine; hepatic encephalopathy; symptomatic uncomplicated diverticulosis of the colon; chronic inflammation of the intestine.

Prevention of infectious complications in colorectal surgery.

ICD-10

I.A00-A09.A09 Diarrhea and gastroenteritis of allegedly infectious origin

XI.K50-K52.K52 Other non-infectious gastroenteritis and colitis

XI.K55-K63.K57 Diverticular Bowel Disease

XI.K70-K77.K72 Hepatic failure, not elsewhere classified

XXI.Z20-Z29.Z29.2 Another type of preventive chemotherapy

Contraindications:

Hypersensitivity (including to other rifamycins).

Carefully:

Pregnancy, breast-feeding.

Pregnancy and lactation:

FDA recommendation category C.

Adequate and well-controlled studies in humans have not been conducted. In animals, caused damage from the fetus, including teratogenic effects. There is no information on the penetration into breast milk.
Use with caution

Dosing and Administration:

Adults and children over 12 years of age are prescribed 200 mg every 8 hours or 400 mg every 8-12 hours. If necessary, the dose and frequency of admission can be changed under the supervision of a doctor. The duration of treatment should not exceed 7 days and is determined by the clinical condition of patients. The repeated course of treatment should be carried out no earlier than in 20-40 days.

Side effects:

The drug is poorly absorbed from the digestive tract, which eliminates the risk of systemic unwanted effects.

From the digestive system: in some cases - nausea, indigestion, vomiting, abdominal pain / colic, which usually pass on their own without the need for dose changes or suspension of therapy.

Allergic reactions: rarely - hives.

Overdose:

Due to low bioavailability, they are insignificant.

Interaction:

Due to low bioavailability, they are insignificant.

Special instructions:

A broad-spectrum antibiotic for topical use (GI disease), a representative of the rifamycin group, a semisynthetic derivative of rifamycin SV.

Instructions

Rifaximin (Rifaximinum)