Silver nitrate (Argenti nitras)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Antiseptics and disinfectants

Included in the formulation
  • Lapis pencil
    pencil externally 
       
    • АТХ:

    R.02.A.A   Antiseptics

    D.08.A.X   Other antiseptics and disinfectants

    D.08.A   Antiseptics and disinfectants

    D.08   Antiseptics and disinfectants

    Pharmacodynamics:

    Silver nitrate has antimicrobial, astringent (at a concentration of up to 2%), cauterizing (at a concentration of more than 5%) properties. During the dissociation of silver nitrate, silver ions cause the precipitation of proteins and cause bactericidal action. Silver nitrate interacts with tissue proteins, which leads to the formation of silver albumin. Then metal silver is recovered from the albumin, which interacts with the active groups of the enzymes, blocks them, thereby disrupting the metabolic processes in the microbial cell. In this regard, silver nitrate after a short-term bactericide has a long bacteriostatic effect. At small concentrations of silver ions, only the precipitation of interstitial proteins occurs and astringent and anti-inflammatory effects occur. In high concentrations, silver ions cause damage to cell membranes and intracellular structures,exerting cauterizing action (friable albuminum are formed).

    Pharmacokinetics:

    Not studied.

    Indications:

    Damage to the skin - erosion, ulcers, excessive granulation, cracks.

    ICD-10

    XII.L20-L30.L25.9   Unspecified contact dermatitis, cause not specified

    XII.L20-L30.L25.8   Unspecified contact dermatitis due to other substances

    XII.L20-L30.L25.5   Unspecified contact dermatitis due to plants other than food

    XII.L20-L30.L25.4   Unspecified contact dermatitis due to food when exposed to skin

    XII.L20-L30.L25.3   Unspecified contact dermatitis due to other chemicals

    XII.L20-L30.L25.2   Unspecified contact dermatitis due to dyes

    XII.L20-L30.L25.1   Unspecified contact dermatitis due to medications in contact with skin

    XII.L20-L30.L25.0   Unspecified contact dermatitis due to cosmetics

    XII.L20-L30.L25   Contact dermatitis, unspecified

    XII.L20-L30.L24.9   Simple irritant contact dermatitis, cause not specified

    XII.L20-L30.L24.8   Simple irritant contact dermatitis due to other substances

    XII.L20-L30.L24.7   Simple irritant contact dermatitis caused by plants other than food

    XII.L20-L30.L24.6   A simple irritant contact dermatitis caused by food products when they come into contact with the skin

    XII.L20-L30.L24.5   Simple irritant contact dermatitis due to other chemicals

    XII.L20-L30.L24.4   A simple irritant contact dermatitis caused by drugs when they come into contact with the skin

    XII.L20-L30.L24.3   Simple irritant contact dermatitis caused by cosmetic means

    XII.L20-L30.L24.2   Simple irritant contact dermatitis due to solvents

    XII.L20-L30.L24.1   Simple irritant contact dermatitis due to oils and lubricants

    XII.L20-L30.L24.0   Simple irritant contact dermatitis due to cleansers

    XII.L20-L30.L24   Simple irritant contact dermatitis

    XII.L20-L30.L23.9   Allergic contact dermatitis, cause not specified

    XII.L20-L30.L23.8   Allergic contact dermatitis due to other substances

    XII.L20-L30.L23.7   Allergic contact dermatitis due to plants other than food

    XII.L20-L30.L23.6   Allergic contact dermatitis caused by food products when they come into contact with the skin

    XII.L20-L30.L23.5   Allergic contact dermatitis due to other chemicals

    XII.L20-L30.L23.4   Allergic contact dermatitis due to dyes

    XII.L20-L30.L23.3   Allergic contact dermatitis caused by drugs when they come into contact with the skin

    XII.L20-L30.L23.2   Allergic contact dermatitis due to cosmetics

    XII.L20-L30.L23.1   Allergic contact dermatitis due to sticky substances

    XII.L20-L30.L23.0   Allergic contact dermatitis due to metals

    XII.L20-L30.L23   Allergic contact dermatitis

    XII.L20-L30.L21.9   Seborrheic dermatitis, unspecified

    XII.L20-L30.L21.8   Other seborrheic dermatitis

    XII.L20-L30.L21.1   Seborrheic children's dermatitis

    XII.L20-L30.L21   Seborrheic dermatitis

    XII.L20-L30.L20.9   Atopic dermatitis, unspecified

    XII.L20-L30.L20.8   Other atopic dermatitis

    XII.L20-L30.L20   Atopic dermatitis

    XII.L20-L30   Dermatitis and eczema

    XIV.N60-N64.N64.0   Fissure and fistula of the nipple

    Contraindications:

    Hypersensitivity, pregnancy, lactation.

    Carefully:

    Children up to 14 years.

    Pregnancy and lactation:

    The category of FDA recommendations is not defined.

    Application during pregnancy and breastfeeding is contraindicated.

    Dosing and Administration:

    Outer (in the form of aqueous solutions, lapis pencils). In otorhinolaryngology: 30-50% solution is applied directly to the affected area gently, at the end of the probe, without touching uninfected areas of the skin, once every 3 days.

    Side effects:

    Allergic reactions.

    Overdose:

    Not described.

    Interaction:

    Incompatible with organic substances (decomposes), with chlorides, bromides, iodides (a precipitate is formed).

    Special instructions:

    Form release: powder for injection 0.25-10% for solutions and 1-2% ointments; a pencil.

    Instructions
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