Sildenafil - instructions for use, dose, side effects, contraindications

Selectively inhibits the enzyme phosphodiesterase cGMP type 5, which regulates the disintegration of cGMP, resulting in increased cGMP level in the cavernous bodies, which leads to increased blood flow in the penis. Activating the path NO/ cGMP produced by sexual stimulation is enhanced by inhibition of type 5 phosphodiesterase, so the effect of the drug is effective only with adequate sexual stimulation.

Pharmacokinetics:

After oral administration, the fasted to 63% is absorbed in the gastrointestinal tract. The maximum concentration in the blood plasma is reached in 30-60 minutes. The connection with plasma proteins is 96%.

The therapeutic effect develops within 30-60 minutes after administration. Metabolism in the liver.

The half-life is 4 hours. Elimination by the kidneys.

Indications:

It is used for erectile dysfunction, it is effective only with sexual stimulation.

ICD-10

V.F50-F59.F52.2 Insufficiency of the genital reaction

XIV.N40-N51.N48.4 Impotence of organic origin

Contraindications:

Simultaneous use of nitrates or donators NO, individual intolerance.

Carefully:

Anatomic deformations of the penis, unstable angina, exacerbation of peptic ulcer of the stomach and duodenum.

Pregnancy and lactation:

The drug is not intended for use in women.

Dosing and Administration:

Recommended dose: inside by 50 mg for 1 hour before sexual intercourse. It is possible to reduce the dose to 25 mg, or increase to 100 mg, depending on the effectiveness of the drug.

The highest daily dose: 100 mg.

The highest single dose: 100 mg.

Side effects:

Central and peripheral nervous system: headache, dizziness, convulsions.

Cardiovascular system: tachycardia, postural hypotension, syncope.

Respiratory system: nasal congestion, exacerbation of bronchial asthma.

Digestive system: dyspeptic disorders, vomiting.

Organs of the senses: reddening of the sclera, transient impairment of vision - clouding, increased perception of light, change in the color of objects. Deafness.

Reproductive system: prolonged erection, priapism.

Allergic reactions.

Overdose:

Increased side effects.

Treatment is symptomatic. Hemodialysis is not effective.

Interaction:

The hypotensive effect is intensified with simultaneous application with nitrates or donators NO.

Simultaneous use of calcium channel blockers, β-blockers, hypoglycemic drugs poses a potential threat to life due to the development of cardiovascular complications.

Special instructions:

With continued erection for 4 hours, a urologist needs medical help, since a violation of the circulation of the penis can lead to ischemia of the penis.

For repeated visual and hearing impairments, the drug should be discontinued.

Instructions

Sildenafil (Sildenafilum)