Included in the formulation
Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):VED
7 nosologies
ONLS
АТХ:H.01.A.C Somatropin and its analogues
H.01.A.C.01 Somatropin
Pharmacodynamics:The analog of human growth hormone, obtained by genetic engineering, containing exactly the same amino acid sequence as in natural somatotropin, stimulates the secretion of insulin-like growth factors-somatomedins. The insulin-like growth factor (IGFR-1) formed in the liver affects the receptors of peripheral tissues, which leads to activation of mitogen-active protein kinase and some types of intermediate metabolism.As a result of the anabolic action of the drug, protein biosynthesis, the growth of muscle and bone tissue, urinary output of nitrogenous products decreases, calcium, phosphorus and sodium are retained.
Pharmacokinetics:After subcutaneous administration, the maximum concentration in the blood plasma is reached after 3-6 hours. Metabolism in the liver.
Half-life is 2-3 hours. Elimination with feces.
Indications:It is used for growth disorders in children due to insufficient endogenous growth hormone, chronic renal failure, manifested by growth retardation, osteoporosis, Turner syndrome, immunodeficiency states with weight loss.
III.D80-D89.D84.9 Immunodeficiency, unspecified
IV.E20-E35.E34.3 Low-growth [dwarfism], not elsewhere classified
XVII.Q90-Q99.Q96 Turner syndrome
XVIII.R50-R69.R62 The absence of the expected normal physiological development
Contraindications:Malignant neoplasms, individual intolerance.
Carefully:Diabetes mellitus, deficiency of thyroid function.
Pregnancy and lactation:Recommendations for FDA - Category C. Contraindicated in pregnancy and lactation.
Dosing and Administration:Subcutaneously or intramuscularly 1 time / day at 0.07-0.1 IU / kg. In some cases, the dose may be raised to 0.14-0.2 IU / kg.
The highest daily dose: 0.14 IU / kg.
The highest single dose: 0.2 IU / kg.
Side effects:Central and peripheral nervous system: headache, paresthesia, rarely - carpal tunnel syndrome in adults, benign intracranial hypertension.
The system of hematopoiesis: rarely - leukemia.
The musculoskeletal system: acromegaly, arthralgia, myalgia, rigidity of the limbs, rarely epiphysiolysis with hip joint lesion.
Endocrine system: diabetes mellitus II type.
Allergic reactions.
Overdose:Hypoglycemia, which turns into hyperglycemia.
Treatment is symptomatic.
Interaction:Simultaneous use with glucocorticoids reduces the therapeutic effect of somatropin.
The use of anabolic steroids enhances the effect of somatropin.
Special instructions:
It is used before the period of bone growth.
Monitoring the content of blood plasma glucose, thyroid hormones.
To avoid the development of lipotrophy, it is recommended to alternate injection sites.