Sulfadiazine (Sulfadiazinum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Sulfonamides

Included in the formulation
  • Dermazin®
    cream externally 
    Sandoz d.     Slovenia
  • Sulfargin®
    ointment externally 
    GRINDEX, JSC     Latvia
    • АТХ:

    J.01.E   Sulfonamides and trimethoprim

    Pharmacodynamics:

    Structural analogue of PABA, necessary for microorganisms for the synthesis of dihydrofolic acid. Competitive blockade of dihydropteroate synthetase of bacteria: disruption of the synthesis of dihydropteroic acid (precursor of tetrahydrofolic acid - cofactor of purine synthesis). Only those microorganisms that are forced to synthesize folic acid themselves are sensitive.

    Pharmacokinetics:

    F 70-100%. Penetrates through the BBB. Relationship with plasma proteins 38-48%. Biotransformation in the liver (acetylation). Half-life of 10 hours, with CRF - 34 hours. Elimination by the kidneys (60-85% within 48-72 hours).

    Indications:

    Prevention and treatment of infectious and inflammatory diseases caused by microorganisms sensitive to sulfadiazine: for burns, bedsores, deep wounds.

    ICD-10

    XII.L80-L99.L89   Decubital ulcer

    XIX.T79.T79.3   Post-traumatic wound infection, not elsewhere classified

    Contraindications:

    Pregnancy, hypersensitivity to sulfadiazine.

    Do not use in newborns.

    Carefully:

    When treating patients with impaired liver function, regular monitoring of sulfadiazine in blood plasma should be performed.In the treatment of patients with impaired renal function, regular monitoring of sulfadiazine in the blood plasma is necessary.

    Pregnancy and lactation:

    Adequate and well-controlled studies in humans and animals have not been conducted. Do not apply! There is no information on the penetration into breast milk. Do not apply!

    The category of FDA recommendations is not defined.

    Dosing and Administration:

    Apply externally usually 2 times / day. Large damaged skin surfaces are covered with sterile gauze, with smaller surfaces this is not required.

    Side effects:

    Hypersensitivity (fever, itching, skin rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant liver necrosis, agranulocytosis, aplastic anemia, other blood diseases), photosensitization.

    Diseases of the blood (fever, sore throat, pallor, unusual bleeding or bruising, unusual fatigue or weakness).

    Hepatitis, Lyell's syndrome.

    Disorders from the central nervous system: confusion, disorientation, euphoria, hallucinations, depression.

    Colitis caused by Clostridium difficile.

    Crystalluria, hematuria; goiter, other thyroid dysfunction, interstitial nephritis, tubular necrosis.

    Nausea, vomiting.

    Overdose:

    Oppression of bone marrow hematopoiesis: leukopenia, agranulocytosis, infection.

    Treatment is symptomatic.

    Interaction:

    Cimetidine - increases the risk of developing leukopenia.

    Special instructions:

    Sulfonilamid of medium duration for external use. Parts of the body treated with the drug are recommended to protect from direct sunlight.

    Instructions
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