Tamsulosin - instructions for use, dose, side effects, contraindications

Selectively blocks postsynaptic α_1A-adrenoceptors located on the neck of the bladder and smooth muscle cells of the prostate gland, as well as the prostatic urethra.

It improves the outflow of urine, reduces irritation and eliminates the manifestations of obstruction of the urinary tract due to benign prostatic hyperplasia.

Pharmacokinetics:

After oral administration, it is completely absorbed in the gastrointestinal tract. The maximum concentration in the blood plasma is reached after 4-5 hours. The connection with plasma proteins is up to 99%.

Therapeutic effect develops 2 weeks after the beginning of the admission. Metabolism in the liver to metabolites that retain pharmacological activity.

The half-life is 9-13 hours. Elimination of the kidneys in the form of metabolites, about 9% unchanged.

Indications:

It is used to treat dysuric disorders in benign prostatic hyperplasia.

ICD-10

XIV.N40-N51.N40 Hyperplasia of the prostate

Contraindications:

Renal and hepatic insufficiency, individual intolerance, children under 18 years of age.

Carefully:

Orthostatic hypotension, including in history, hypersensitivity.

Pregnancy and lactation:

Not applicable.

Dosing and Administration:

Inside, 400 mg once a day after breakfast.

The highest daily dose: 400 mg.

The highest single dose: 400 mg.

Side effects:

Central and peripheral nervous system: asthenia, headache, dizziness, syncope, sleep disorders.

The cardiovascular system: orthostatic hypotension, tachycardia, cardialgia.

Digestive system: nausea, vomiting, diarrhea, or constipation.

Musculoskeletal system: backache.

Sense organs: rhinitis, visual impairment.

Dermatological reactions: a rash.

Reproductive system: priapism, violation of libido, retrograde ejaculation.

Allergic reactions.

Overdose:

Increased side effects.

Treatment is symptomatic.

Interaction:

Cimetidine increases the concentration of tamsulosin in the blood plasma.

Furosemide lowers the concentration of tamsulosin in the blood plasma.

Warfarin and diclofenac increase the rate of excretion of tamsulosin.

When used simultaneously with other α₁-adrenoceptor increases the risk of developing arterial hypotension.

Special instructions:

Before using tamsulosin, a full examination of patients is recommended to exclude malignant neoplasm of the prostate.

In the treatment it is not recommended to drive vehicles and work with moving mechanisms.

Instructions

Tamsulosin (Tamsulosinum)