Telbivudine (Telbivudinum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Antiviral drugs (excluding HIV)

Included in the formulation
  • Sebivo
    pills inwards 
    Novartis Pharma AG     Switzerland
    • Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):

    VED

    АТХ:

    J.05.A.F.11   Telbivudine

    Pharmacodynamics:

    Synthetic analogue of thymidine nucleoside, active against hepatitis B virus polymerase. After phosphorylation by cellular kinases to telvibudine-5-triphosphate competes with natural thymidine-5-triphosphate, is included in viral DNA, breaking the chain. As a result, replication of hepatitis B virus is interrupted.

    The drug is active only against the hepatitis B virus, has no effect on other DNA and RNA viruses.

    Pharmacokinetics:

    After oral administration, an empty stomach is absorbed up to 40% in the gastrointestinal tract. The maximum concentration in the blood plasma is reached after 2 hours. Evenly distributed between the blood plasma and the intercellular fluid. The connection with plasma proteins is not more than 3.3%.

    The half-life is 40-49 hours. Elimination of the kidneys unchanged.

    Indications:

    It is used for the treatment of chronic viral hepatitis B.

    ICD-10

    I.B15-B19.B18.1   Chronic viral hepatitis B without delta-agent

    Contraindications:

    Individual intolerance, children under 18 years.

    Carefully:

    Hypersensitivity.

    Pregnancy and lactation:

    Recommendations for FDA - Category C. It is used with caution during pregnancy and lactation in cases where the intended benefit exceeds the risk to the fetus and newborn.

    Dosing and Administration:

    Inside to 600 mg once a day.

    The highest daily dose: 600 mg.

    The highest single dose: 600 mg.

    Side effects:

    Central and peripheral nervous system: headache, dizziness, hypoesthesia, peripheral neuropathy, sciatica.

    Respiratory system: cough.

    Digestive system: diarrhea, gastralgia, nausea.

    Musculoskeletal system: arthralgia, myopathy, myalgia, pain in the back and extremities, muscle spasms.

    Dermatological reactions: a rash.

    Allergic reactions.

    Overdose:

    Cases of overdose are not described.

    Treatment is symptomatic.

    Interaction:

    With simultaneous use with antiretroviral drugs, lactic acidosis, hepatomegaly with steatosis develops, a lethal outcome is possible.

    Special instructions:

    Function check liver during treatment and for several months after its termination.

    Instructions
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