Included in the formulation
АТХ:R.02.A Drugs for the treatment of throat diseases
R.02.A.A.20 Other drugs
Pharmacodynamics:Combined drug with antiseptic and local anesthetic action. Included in the chlorhexidine has a bactericidal and bacteriostatic effect on gram-positive and gram-negative microorganisms. Especially active against Streptococcus mutans, Streptococcus salivarius, Escherichia coli and anaerobic bacteria. Less effective against such microorganisms as Streptococcus spp., Proteus spp., Pseudomonas, Klebsiella spp., Veillonella spp. It also shows fungicidal properties with respect to Candida albicans.
Tetracaine has a peripheral local anesthetic effect on the receptors of the mucous membrane of the mouth and pharynx. Anesthesia occurs 1-2 minutes after application to the surface of the mucous membrane and lasts for 15-20 minutes.
Pharmacokinetics:Tetracaine is easily and completely absorbed through the mucous membranes. The binding with plasma proteins is high. Completely hydrolyzed by cholinesterase for 1-2 hours to form para-aminobenzoic acid compounds. It is excreted by the kidneys and with bile, while it is partially subjected to hepatic intestinal recirculation.
There are no clinical data on the absorption of chlorhexidine through the mucous membrane of the human mouth. Chlorhexidine can persist in saliva up to 8 hours. Virtually not absorbed from the digestive tract. It is excreted primarily through the intestine (90%), less than 1% is excreted by the kidneys.
Indications:Prevention, etiotropic and symptomatic treatment of infectious and inflammatory diseases of the oral cavity and pharynx (pharyngitis, tonsillitis, the initial stage of angina, periodontitis, stomatitis, gingivitis, condition after tonsillectomy or tooth extraction, etc.). Complex therapy of angina (appointed at the first signs of the disease - pain in the throat and persheniya).
X.J00-J06.J02 Acute pharyngitis
X.J00-J06.J03 Acute tonsillitis
XI.K00-K14.K05 Gingivitis and periodontal disease
XI.K00-K14.K05.4 Periodontal disease
XI.K00-K14.K12 Stomatitis and related lesions
Contraindications:Hypersensitivity, damage or inflammation of the mucous membranes in the highly vascularized areas, allergic reactions to local anesthetics and chlorhexidine in the anamnesis, children's age (till 10 years).
Carefully:Pregnancy and lactation, hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, oxalosis and urolithiasis.
Pregnancy and lactation:Use during pregnancy and lactation only after consulting a doctor. Action category for the fetus by FDA - B (for chlorhexidine) / C (for tetracaine). Controlled studies in humans have not been conducted, there has been no teratogenic effect on animals.
Dosing and Administration:Locally (in the form of a spray). Sprayed on the mucous membrane of the mouth and throat when breathing is delayed: adults and children over 15 years - 1-2 sprayings per reception up to 6 times a day; children from 10 to 15 years - 1-2 sprayings per reception up to 3 times a day. The course of treatment is no more than 5 days.
Side effects:In rare cases, allergic reactions, a change in the sensitivity of the oral mucosa.
Overdose:Symptoms (when using a dosage form in the form of a spray): dizziness, general weakness, cyanosis, agitation, restlessness, muscle tremor, respiratory failure, nausea, vomiting.
Treatment: gastric lavage, the appointment of salt laxatives; symptomatic therapy.
Interaction:Sucrose, polysorbate 80, insoluble salts of magnesium, zinc and calcium reduce the effect of chlorhexidine.
Tetracaine reduces antibacterial activity sulfanilamide preparations. Vasoconstrictors prolong the effect and reduce toxicity.
Drugs that inhibit cholinesterase (anti-asthma, cyclophosphamide, thiotepa and others), reduce the metabolism of tetracaine and increase its toxicity.
Anticoagulants (dalteparin sodium, sodium enoxaparin, heparin sodium, warfarin) increase the risk of bleeding.
When using tetracaine with drugs that inhibit MAO (furazolidone, procarbazine, selegiline), the risk of lowering blood pressure increases.
Tetracaine enhances and lengthens the effect muscle relaxants.
Beta-blockers slow the metabolism of tetracaine, increasing its toxicity (decreased hepatic blood flow).
Special instructions:Avoid contact with the respiratory system and eyes. If after 3 days after the start of treatment the symptoms of the disease do not disappear or the deterioration of the course of the disease is observed, it is necessary to determine the expediency of further use of the drug. Children can be used from the age of 10 if the child is able to hold their breath while spraying the product. Please note that one dose of the spray contains 83 mg of absolute ethanol.
It is not recommended to use simultaneously with oral and throat preparations containing iodine.
Take at least 30 minutes before the start of driving. If this recommendation is complied with, the ability to drive vehicles and control mechanisms is not affected.