Thiamazole (Thiamazolum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Thyroid hormones, their analogs and antagonists (including antithyroid drugs)

Included in the formulation
  • Mercazolil
    pills inwards 
    MARBIOFARM, OJSC     Russia
  • Mercazolil
    pills inwards 
    HEALTH PHARMACEUTICAL COMPANY, LTD.     Ukraine
  • Mercazolil
    pills inwards 
    AKRIKHIN HFK, JSC     Russia
  • Tirozol®
    pills inwards 
    Merck KGaA     Germany
    • Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):

    ONLS

    VED

    АТХ:

    H.03.B.B   Imidazole derivatives containing sulfur

    H.03.B.B.02   Thiamazole

    Pharmacodynamics:

    It blocks peroxidase, inhibits iodination of tyrosine, reducing the synthesis of tetraiodothyroxine and tetraiodothyronine - thyroxine. Reduces the basal metabolism, accelerates the excretion of the thyroid gland of iodides, and therefore increases the reciprocal activation of the synthesis of the pituitary thyroid-stimulating hormone, leading to hyperplasia of the thyroid gland.

    Pharmacokinetics:

    After ingestion, up to 98% is absorbed in the gastrointestinal tract. The maximum concentration in blood plasma is reached after 1 hour. Virtually does not bind to plasma proteins, it concentrates in the thyroid gland, where it undergoes primary metabolism. It penetrates the placental barrier and enters the breast milk.

    Metabolism in the liver and kidneys.

    The elimination half-life is 4 hours. Elimination by the kidneys (70%) and with feces (30%).

    Pharmacological parameters do not depend on the functions of the thyroid gland.

    Indications:

    It is used for the treatment of diffuse toxic goiter, relief of thyrotoxic crisis, used in combination therapy with radioactive iodine and thyroid hormone preparations.

    ICD-10

    IV.E00-E07.E01.0   Diffusive (endemic) goiter associated with iodine deficiency

    IV.E00-E07.E05   Thyrotoxicosis [hyperthyroidism]

    Contraindications:

    Leukopenia, granulocytopenia, individual intolerance.

    Carefully:

    Patients with large thyroid glands, leading to a narrowing of the trachea.

    Pregnancy and lactation:

    Recommendations for FDA - Category C. Contraindicated in pregnancy and lactation.

    Dosing and Administration:

    Use in children

    In the morning, after eating 300-500 mg.

    Adults

    Inside, 20-40 mg / day for 2-4 admission.

    The highest daily dose: 40 g.

    The highest single dose: 10 g.

    Side effects:

    Central and peripheral nervous system: headache, rarely - polyneuropathy.

    The system of hematopoiesis: aplastic anemia, agranulocytosis, leukopenia, rarely generalized lymphadenopathy

    Digestive system: nausea, vomiting, hepatitis, cholestatic stomach.

    Musculoskeletal system: arthralgia, myalgia.

    Dermatological reactions: alopecia, hyperpigmentation of the skin.

    Urinary system: rarely - jade.

    Allergic reactions.

    Overdose:

    Hypothyroidism.

    Treatment is symptomatic.

    Interaction:

    Lack of iodine increases, and excess - weakens the effect of thiamazole.

    β-adrenoblockers, lithium preparations, amiodarone, reserpine, - enhance the effects of thiamazole.

    Simultaneous use with sulfonamides, myelotoxic agents, metamizole sodium increases the risk of developing leukopenia.

    The antithyroid effect increases with simultaneous application with gentamycin.

    Special instructions:

    Monitoring the blood formula.

    For 1-2 weeks before the operation, it is recommended to replace thiamazole with iodine-containing preparations.

    Instructions
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