Included in the formulation
АТХ:N.06.A.X Other antidepressants
N.06.A.X.14 Tianeptine
Pharmacodynamics:Strengthens the reuptake of serotonin by neurons of the cerebral cortex and hippocampus, increases the spontaneous activity of pyramidal cells and accelerates their recovery after functional inhibition.
Occupies an intermediate position between stimulant and sedative antidepressants, has a positive effect on patients with mood disorders, with somatic complaints on the part of the digestive tract, improves behavior and mood during abstinence in people with chronic alcoholism.
In therapeutic doses does not have cardiotoxic and holinoliticheskim action, does not affect the reaction rate and does not cause sleep disorders.
Pharmacokinetics:After oral administration, the fasting is quickly and completely absorbed in the gastrointestinal tract. The connection with plasma proteins is 94%. Quickly distributed to the body, it penetrates the blood-brain and placental barrier, enters the breast milk.
Metabolism in the liver by β-oxidation and N-detylation.
Half-life is 2.5 hours. Elimination of the kidneys in the form of metabolites, about 8% - unchanged.
Indications:It is used to treat moderately severe, mild and severe depressive conditions, including in geriatric practice and in patients with somatic complaints, is used to correct behavior and mood in the state of alcohol and narcotic abstinence.
V.F30-F39.F31 Bipolar affective disorder
V.F30-F39.F32 Depressive episode
V.F30-F39.F33 Recurrent depressive disorder
V.F40-F48.F41.2 Mixed anxiety and depressive disorder
Contraindications:Individual intolerance.
Pregnancy and lactation:Recommendations for FDA - Category C. Contraindicated in pregnancy and lactation.
Dosing and Administration:Inside before eating 12.5 mg (1 tablet) 3 times / day.
The highest daily dose: 37.5 mg.
The highest single dose: 12.5 mg.
Side effects:Central and peripheral nervous system: nightmares, confusion, hallucinations, headache, "sensation of a coma in the throat", tremor, syncope.
Respiratory system: shortness of breath.
Cardiovascular system: tachycardia, stenocardia.
Digestive system: anorexia, dry mouth, constipation, flatulence.
Musculoskeletal system: myalgia, back pain.
Allergic reactions.
Overdose:Increased side effects.
Treatment is symptomatic.
Interaction:Simultaneous use with nonselective monoamine oxidase inhibitors is dangerous due to the development of collapse, hyperthermia, convulsive syndrome and death. It is necessary to observe an interval of 2 weeks between the appointment of MAO inhibitors and tianeptine.
Special instructions:The drug should be discontinued gradually, within 1-2 weeks.
Reception of the drug must be discontinued 24-48 hours before surgery with general anesthesia.