Tinidazole (Tinidazolum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Antimicrobial, antiparasitic and anthelmintic agents

Included in the formulation
  • Tinidazole
    pills inwards 
    BIOKOM, CJSC     Russia
  • Tinidazole
    pills inwards 
    OZONE, LLC     Russia
  • Tinidazole-Acry®
    pills inwards 
    AKRIKHIN HFK, JSC     Russia
    • АТХ:

    P.01.A.B.02   Tinidazole

    P.01.A.B   Nitroimidazole derivatives

    Pharmacodynamics:

    The nitro-5-imidazole derivative has an antibacterial and antiprotozoal effect. It recovers 5-nitro group due to transport proteins of anaerobic bacteria and protozoan microorganisms. The reduced 5-nitro group of tinidazole inhibits the synthesis of nucleic acids from the DNA of microorganism cells, which leads to their death.

    It is active against Gardnerella vaginalis, Giardia lamblia, Entamoeba histolytica, Trichomonas vaginalis, and also with respect to obligate anaerobes Bacteroides spp. (at t.h. B. distasonis, B. ovatus, B. fragilis, B. vulgatus, B. thetaiotaomicron), Fusobacterium spp., Prevotella spp. (Prevotella bivia, Prevotella buccae, Prevotella disiens), Veillonella spp., and some gram-positive microorganisms (Clostridium spp., Eubacterium spp., Peptococcus spp., Peptostreptococcus spp.).

    With a mixed flora, it acts synergistically with antibiotics against aerobic bacteria.

    Pharmacokinetics:

    After ingestion during meals, it is completely absorbed in the gastrointestinal tract. The maximum concentration in blood plasma is reached after 2 hours. The connection with plasma proteins is 12%.

    Penetrates through the blood-brain and placental barrier, excreted in breast milk for 72 hours after ingestion.Metabolism in the liver by dehydroxylation, resulting in the appearance of two active metabolites, enhancing the pharmacological effect.

    The half-life is 12-14 hours. Elimination with feces and kidneys. It is reversed in the renal tubules.

    Indications:

    It is used for the treatment of trichomoniasis, amoebiasis, giardiasis, infections caused by anaerobic flora, and is prescribed for the prevention of postoperative complications.

    ICD-10

    I.A00-A09.A06   Amebiasis

    I.A00-A09.A07.1   Giardiosis (giardiasis)

    I.A50-A64.A59   Trichomoniasis

    XI.K20-K31.K25   Stomach ulcer

    XI.K20-K31.K26   Duodenal ulcer

    XXI.Z20-Z29.Z29.8   Other specified preventive measures

    Contraindications:

    Organic damage to the central nervous system (epilepsy), hepatic insufficiency, individual intolerance.

    Carefully:

    Disturbances of microcirculation, diabetes mellitus.

    Pregnancy and lactation:Recommendations for FDA - Category B. Contraindicated in I trimester of pregnancy and lactation.
    Dosing and Administration:

    Applies from the age of 5

    With intestinal amebiasis: inside with food 30-60 mg 1 time / day for 3 days.

    At an amoebic abscess of a liver: inside during meal on 50-60 mg 1 time / sut within 5 days.

    Adults

    Inside with food: 2 g (4 tablets) 1 time / day for 2-3 days.

    The highest daily dose: 2 g.

    The highest single dose: 2 g.

    Side effects:

    Central nervous system: headache, dizziness.

    Hematopoietic system: leukocytosis or leukopenia.

    Digestive system: nausea, sensation of metallic taste in the mouth, loss of appetite, constipation or diarrhea.

    Urinary system: coloration of urine in red-brown color due to metabolite 2-oxytinidazole.

    Local reactions: itching, burning, irritation of the mucous membrane of the vagina.

    Allergic reactions.

    Overdose:

    Vomiting, diarrhea, ataxia, paresthesia, convulsions.

    Treatment is symptomatic. Effective hemodialysis.

    Interaction:

    With the simultaneous use of alcohol, disulfiramoid reactions develop: skin hyperemia, vomiting, cramping pains in the lower abdomen.

    Strengthens the effect of indirect coagulants.

    It is not compatible with nondepolarizing muscle relaxants (faithful bromide).

    With simultaneous application accelerate elimination and reduce the concentration of tinidazole in blood plasma drugs that stimulate enzymes of microsomal oxidation in the liver (feniotion, phenobarbital).

    Enhances the toxic effects of lithium preparations.

    With simultaneous use with cimetidine, the concentration of tinidazole in the blood serum increases, which leads to an increase in side effects.

    Special instructions:

    When treating Trichomonas and Candida colpitis, women need treatment for sexual partners and abstinence from sexual activity for the period of taking the drug.

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