Included in the formulation
АТХ:J.04.A.K Other antituberculous drugs
Pharmacodynamics:Has a bacteriostatic effect against mycobacteria tuberculosis and causative agents leprosy due to the formation of complex salts with copper ions. Strengthens the phagocytic activity of monocytes and neutrophils when used in small doses.
Pharmacokinetics:After ingestion, up to 90% is absorbed in the gastrointestinal tract. The maximum concentration in the blood plasma is reached after 6 hours. Metabolism in the liver.
The half-life is 13 hours. Elimination by the kidneys, about 33% - in unchanged form.
Indications:It is used to treat tuberculosis of mucous membranes and serous membranes, with lymphadenitis, scrofuloderm, in the early stages of leprosy.
I.A15-A19 Tuberculosis
I.A15-A19.A18.4 Tuberculosis of skin and subcutaneous tissue
I.A30-A49.A30.9 Leprosy, unspecified
Contraindications:Renal and hepatic insufficiency, hemopoiesis disorders, individual intolerance.
Carefully:Diabetes mellitus, peptic ulcer and duodenal ulcer, ulcerative colitis.
Pregnancy and lactation:Recommendations for FDA - Category C. Contraindicated in pregnancy and lactation.
Dosing and Administration:Use in children
Contraindicated before 12 years of age.
Inside after eating, drinking a glass of milk, tea, water, to 0.0005 g / kg / day.
The highest daily dose: 0.05 g.
Adults
Inside after eating, drinking a glass of milk, tea, water, 0.05 g 2-3 times / day.
The highest daily dose: 0.15 g.
The highest single dose: 0.05 g.
Side effects:Central and peripheral nervous system: headache.
The system of hematopoiesis: anemia, thrombocytopenia, agranulocytosis.
Digestive system: deterioration of appetite, abdominal pain, hepatitis.
Dermatological reactions: exfoliative dermatitis.
Urinary system: albuminuria, cylindruria, renal failure.
Allergic reactions.
Overdose:Increased side effects, acute renal failure.
Treatment is symptomatic.
Interaction:With the simultaneous use of isoniazid, streptomycin, PASK, the therapeutic effect of thiocetazone is enhanced.
Forms cross-sensitivity with protionamide and ethionamide.
Special instructions:Monitoring the functions of the kidneys, liver, hematopoietic system.
It is not used to treat tuberculous meningitis. The combination with diaphenylsulfone in the treatment of leprosy is not recommended.