Trimebutin (Trimebutinum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Spasmolytics myotropic

Included in the formulation
  • Neobutin®
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    OBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSC     Russia
  • Neobutin®
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    SEGMENTA FARM, LLC     Russia
  • Neobutin® Retard
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    OBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSC     Russia
  • Trimedat®
    pills inwards 
    VALENTA PHARM, PAO     Russia
  • Trimedat® Valenta
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    VALENTA PHARM, PAO     Russia
  • Trimedat® forte
    pills inwards 
    VALENTA PHARM, PAO     Russia
    • АТХ:

    A.03.A.A.05   Trimebutin

    Pharmacodynamics:

    Has an effect on the enkephalinergic system of the intestine, regulating its peristalsis. Regulates motor activity without affecting the central nervous system, restoring normal physiological activity of the intestinal muscles in various gastrointestinal disorders caused by motor disorders. Due to the normalization of visceral sensitivity provides analgesic effect in abdominal pain syndrome.

    Pharmacokinetics:

    Quickly absorbed from the digestive tract. The maximum concentration in the blood plasma is achieved after 1-2 hours. Bioavailability of about 4-6%. It penetrates insignificantly through the placental barrier. Biotransformiruetsya in the liver and excreted in the urine, mainly in the form of metabolites. The half-life is about 12 hours.

    Indications:

    For oral administration and rectally: symptomatic treatment of pain associated with functional disorders of the gastrointestinal tract and bile duct.

    For parenteral use: symptomatic treatment of severe pain manifestations in functional disorders of the gastrointestinal tract; treatment of postoperative paralytic ileus and in preparation for X-ray and endoscopy studies.

    ICD-10

    XI.K55-K63.K56   Paralytic ileus and intestinal obstruction without a hernia

    XI.K80-K87.K80   Gallstone disease [cholelithiasis]

    XI.K80-K87.K82.8   Other specified diseases of the gallbladder

    XVIII.R10-R19.R10.4   Other and unspecified abdominal pain

    XXI.Z40-Z54.Z51.4   Preparatory procedures for subsequent treatment, not elsewhere classified

    Contraindications:

    Hypersensitivity.

    Carefully:Predisposition to allergic reactions.
    Pregnancy and lactation:

    It is not recommended to use during pregnancy and lactation (breastfeeding).

    Category of recommendations for FDA is not defined.

    Dosing and Administration:

    Daily intake for oral administration - up to 300 mg, rectally - 100-200 mg. Intramuscular or intravenous single dose - 50 mg.

    Side effects:

    Possible: skin allergic reactions; with intravenous administration - short-term fainting.

    Overdose:

    Not described.

    Interaction:

    Not described.

    Special instructions:

    It is necessary to strictly observe the compliance of the used dosage form with indications for use.

    Instructions
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