Included in the formulation
АТХ:J.05.A.09 Famciclovir
Pharmacodynamics:Transforms in the body in penciclovir, enters the virus-infected cells, where under the action of viral thymidine kinase is converted to monophosphate, which, with the participation of cellular enzymes, turns into triphosphate. Penciclovir triphosphate is found in virus-infected cells for more than 12 hours, suppressing the synthesis of viral DNA in them, violating the replication of viruses Herpes simplex (types 1 and 2), Varicella zoster, Epstein-Barr and cytomegalovirus.
Pharmacokinetics:After oral administration, fasted to 77% is absorbed in the gastrointestinal tract. The maximum concentration in the blood plasma is reached after 45 minutes. The connection with plasma proteins is 20%.
Metabolism in the liver. Do not cumulate.
The elimination half-life is 2 hours. Elimination by the kidneys in the form of penciclovir.
Indications:It is used to treat infections caused by Varicella zoster (herpes zoster), including herpes zoster with complications from the side of the eye. Used for infections caused by Herpes simplex (type I and II): primary infection, recurrent chronic infection.
I.A50-A64.A60 Anogenital herpetic viral infection [herpes simplex]
I.B00-B09.B00 Infections caused by the herpes simplex virus [herpes simplex]
I.B00-B09.B02 Shingles [herpes zoster]
Contraindications:Individual intolerance.
Carefully:Pregnancy and lactation, kidney failure, hypersensitivity, children under 18 years.
Pregnancy and lactation:Recommendations for FDA - Category B. It is used with caution during pregnancy and lactation in cases where the intended benefit exceeds the risk to the fetus and newborn.
Dosing and Administration:Inside, 250 mg 3 times a day or 500 mg 2 times a day. For patients with weakened immunity and HIV infection, the dose increases to 500 mg 3 times a day.
The highest daily dose: 1.5 g.
The highest single dose: 500 mg.
Side effects:Central and peripheral nervous system: headache, rarely dizziness, hallucinations, confusion.
Hemopoietic system: thrombocytopenia, granulocytopenia.
Digestive system: nausea, vomiting.
Dermatological reactions: a rash.
Allergic reactions.
Overdose:Headache, convulsions, drowsiness, coma, acute renal failure.
Treatment is symptomatic, hemodialysis is effective.
Interaction:Probenecid and other drugs that affect the function of the kidneys can change the level of penciclovir in the blood plasma.
Special instructions:In the presence of clinical manifestations of genital herpes it is recommended that the drug be taken together by sexual partners who should avoid sexual contact.