Fluocortolone (Fluocortolonum)

Glucocorticosteroid for external and topical application.Has anti-inflammatory, antiexudative, anti-allergic and antipruritic effect.

It binds to specific receptors located in the cytoplasm of cells of target organs and activates the synthesis of mRNA; induces the formation of lipocortin proteins, one of which is lipomodulin, inhibits the activity of phospholipase A2. The disruption of the formation of arachidonic acid actually means inhibition of the synthesis of prostaglandins, since arachidonic acid is a substrate for further metabolism along the cyclooxygenase pathway, and also along the lipoxygenase pathway, with appropriate inhibition of leukotriene synthesis.

The anti-inflammatory effect of fluocortolone is potentiated by its ability to inhibit the expression of COX-2 genes, which also leads to a decrease in the synthesis of prostaglandins in the inflammatory focus, including pro-inflammatory prostaglandins E2 and I2. Fluocortolone inhibits the expression of molecules of intercellular adhesion in the endothelium of blood vessels, violating the penetration of neutrophils and monocytes into the focus of inflammation.

With topical application fluocortolone prevents the accumulation of neutrophils,which leads to a decrease in the production of inflammatory exudates and lymphokines, inhibition of migration of macrophages, a reduction in inflammatory infiltration and granulation.