Included in the formulation
АТХ:N.07.B.B Drugs used in alcohol dependence
Pharmacodynamics:It blocks the enzymatic biotransformation of ethyl alcohol, which leads to an increase in the concentration of the metabolite of ethyl alcohol - acetaldehyde. This condition is accompanied by a sensation of blood rush to the face, vomiting, tachycardia, dyspnea, which makes it extremely unpleasant to use ethyl alcohol after taking the drug and contributes to the formation of a conditioned reflex aversion to the taste and smell of alcohol.
The sensitizing effect of cyanamide on alcohol is detected after 45-60 minutes and lasts about 12 hours.
Pharmacokinetics:Not described.
Indications:It is used to treat chronic alcoholism and prevent its recurrence.
V.F10-F19.F10.2 Mental and behavioral disorders caused by alcohol use - addiction syndrome
Contraindications:Heavy cardiac, pulmonary, hepatic and renal insufficiency, individual intolerance, children under 18 years of age.
Carefully:Stomach ulcer and duodenal ulcer in the acute stage, epilepsy, diabetes mellitus, hypothyroidism, nephritis,severe cardiovascular diseases, endarteritis, age over 60 years, hypersensitivity.
Pregnancy and lactation:Recommendations for FDA - Category C. Contraindicated in pregnancy and lactation.
Dosing and Administration:Inside to 36-75 mg (12-25 drops) 2 times a day after 12 hours.
The highest daily dose: 150 mg (50 drops).
The highest single dose: 75 mg (25 drops).
Side effects:Central and peripheral nervous system: fatigue, drowsiness.
Hemopoietic system: transient leukocytosis.
Dermatological reactions: a rash.
Sense organs: noise in ears.
Allergic reactions.
Overdose:Increased side effects.
Treatment is symptomatic.
Interaction:Incompatible with preparations of aldehyde group: with products of chloral and paraldehyde.
It is possible to develop a reaction to alcohol contained in certain medicines and food products.
Simultaneous use with aldehyde dehydrogenase inhibitors (metronidazole, isoniazid, phenytoin) enhances the reaction with alcohol. Cyanamide can be used after taking disulfiram no earlier than 10 days later.
With the simultaneous reception with alcohol, weakness develops, difficulty breathing, marked hyperemia of the skin, a sensation of pulsation in the head and neck, chest pain, blurred vision, tachycardia, nausea, increased sweating. In more severe cases - arterial hypotension, vomiting, respiratory depression, collapoid state. The nature and severity of the symptoms is dose-dependent. Treatment: symptomatic therapy aimed at maintaining the functions of respiration and cardiovascular system, intravenous administration of antihistamines.
Special instructions:It is used only under the supervision of a doctor and with the patient's consent to the therapy.
Treatment can be started only after 12 hours from the last intake of ethanol. With prolonged use, it is necessary to monitor the function of the thyroid gland.