Included in the formulation
АТХ:G.02.A.B Preparations of ergot alkaloids
G.02.A.B.03 Ergometrine
Pharmacodynamics:One of the main alkaloids is ergot.Has a direct effect on the uterus, causing a persistent tonic contraction of the myometrium, and also increasing the frequency of contractions. In connection with the uterotonic effect is used for atony and hypotension of the uterus and associated uterine bleeding. Hemostatic effect in this case is due mainly to the compression of blood vessels with a reduction in myometrium. It can also accelerate the involution of the uterus in the postpartum period.
In small doses does not have a significant effect on blood circulation. Has a minor sedative effect, suppresses the production of prolactin, inhibits the secretion of breast milk.
Pharmacokinetics:Quickly absorbed after ingestion or intramuscular injection. Uterotonic action in the postpartum period with oral administration begins in 6-15 minutes, with intramuscular injection - after 2-3 minutes, with intravenous administration - less than 1 minute; duration of action about 3 hours after ingestion and intramuscular injection, 45 minutes after intravenous administration, but rhythmic contractions of the uterus continue for at least 3 hours.
Metabolism in the liver. Half-life is 32 minutes. Elimination by the kidneys in the form of metabolites (95%).
Indications:Hypo- and atonic uterine bleeding (including in the early postpartum period, after manual separation of the afterbirth), postoperative (caesarean section, removal of fibroids) and postabortinal uterine bleeding, sub-evolution of the uterus after childbirth and abortion, menorrhagia.
XIV.N80-N98.N85.3 Subinvolution of the uterus
XV.O60-O75.O67 Childbirth and delivery, complicated by bleeding during labor, not elsewhere classified
XV.O60-O75.O72 Postpartum hemorrhage
XV.O80-O84.O82 Singleton births, delivery was by caesarean section
XX.Y83-Y84.Y83.8 Other Surgery
Contraindications:I and II (before the eruption of the fetal head) periods of labor, obliterating vascular diseases, sepsis, cardiovascular pathology, pronounced impaired liver or kidney function, hyperthyroidism. individual intolerance of ergot preparations.
Carefully:Coronary heart disease, hepatic and renal failure, stenosis of the mitral valve
Pregnancy and lactation:Recommendations for FDA - not determined. It is not used in pregnancy, can have a depressing effect on lactation.
Dosing and Administration:Inside, intramuscularly, intravenously or directly into the body of the uterus (after caesarean section) or the cervix (after the termination of pregnancy) - 200-500 mcg. Inside - 200-400 mcg 2-3 times a day. The maximum dose for parenteral administration is 1 mg per day.
Side effects:Central and peripheral nervous system: headache, dizziness, rarely - hallucinations.
The cardiovascular system: increased arterial pressure, arrhythmia, spasm of peripheral vessels.
Respiratory system: shortness of breath is possible.
Dermatological manifestations: hyperhidrosis, rash.
Reproductive system: hypogalactia.
Allergic reactions.
Overdose:Symptoms: stenocardia, miosis, confusion, numbness of hands or feet, weak pulse, respiratory depression, thirst, tetany of the uterus.
Treatment: symptomatic.
Interaction:Strengthens the vasoconstrictive effects of sympathomimetics.
With simultaneous application with oxytocin, the development of hypertensive crisis is possible.
Special instructions:The drug should be administered only in a specialized hospital, with strict medical supervision HELL, heart rate, contractile activity of the uterus.
With extreme caution should be used in the III period of childbirth and the early postpartum period due to the danger of developing arterial hypertension.
With prolonged use, it is possible to develop ergotism.
With intravenous administration, there is risk of increased blood pressure.