Included in the formulation
АТХ:M.05.B.A.01 Ethidronic acid
Pharmacodynamics:Pharmacological action - hypocalcemic, regulating calcium-phosphorus metabolism, stimulating osteogenesis, nephrolitholithic.
Is an active complexon. Inhibits normal and pathological bone resorption, reduces bone formation, reduces the number and activity of osteoclasts. Prevents crystal formation and crystal growth in the urinary tract.
Pharmacokinetics:After ingestion, it is well absorbed. Half-life is about 24 hours. It is not biotransformed. Excreted by the kidneys.
Indications:Nephrourolythiasis, hypervitaminosis D, hyperparathyroidism, hypercalcemia in malignant neoplasms, interstitial nephritis, osteoporosis, including secondary (treatment and prevention); osteopenia and osteoporosis with prolonged immobilization (prevention), chronic intoxication with heavy metals (lead, tin, antimony, strontium, magnesium, silicon). As part of complex therapy in adults: bronchial asthma (of light and medium-heavy course - in order to stabilize the membranesimmunocompetent cells), hormone-dependent bronchial asthma (prevention of osteoporosis).
XIII.M86-M90.M90.8 * Osteopathy in other diseases classified elsewhere
XIII.M80-M85.M82 * Osteoporosis in diseases classified elsewhere
XIII.M80-M85.M81.9 Osteoporosis, unspecified
XIII.M80-M85.M81.4 Medicinal osteoporosis
XIII.M80-M85.M81.2 Osteoporosis caused by immobility
IV.E20-E35.E21 Hyperparathyroidism and other disorders of the parathyroid [parathyroid] gland
IV.E65-E68.E67.3 Hypervitaminosis D
XIV.N20-N23 Urolithiasis disease
XIII.M86-M90.M89.9 Disease of bones, unspecified
X.J40-J47.J45 Asthma
XIX.T51-T65.T56 Toxicity of metals
Contraindications:Hypersensitivity, hypocalcemia, pregnancy, breastfeeding, children under 10 years (up to 16 years for the treatment of bronchial asthma in the complex therapy).
Carefully:With caution apply etidronovuyu acid in patients with chronic enterocolitis.
When used in patients with reduced renal function, the dosage regimen should be adjusted.
Pregnancy and lactation:Action category for the fetus by FDA - C. Ethidronic acid contraindicated for use in pregnancy.
It is not established whether the etidronic acid with breast milk. Do not apply.
Dosing and Administration:Individual. For adults and children over 10 years of age, the daily dose is 10 mg / kg.
Side effects:Pain in the bones and tendons - in patients with Paget's disease, more often in the affected bones, for 4-6 weeks of initial therapy, at doses greater than 5 mg / kg or with therapy for more than 6 months.
Osteomalacia - in patients taking high doses - more than 20 mg / kg, or with continuous intake of etidronate for more than 6 months.
Diarrhea, nausea, metallic taste in the mouth.
Rarely: allergic reactions, uveitis, iritis, scleritis, episcleritis.
Long-term administration of large doses of etidronic acid may cause magnesium deficiency and rickets-like effect; for the prevention of minimal doses of magnesium-containing drugs and periodically - therapeutic doses of vitamin D. It is also possible to observe a change in lipid peroxidation, which is eliminated by taking 3-5 drops of a 5% vitamin E oil solution once a day.
Overdose:Symptoms: it is possible to strengthen the above described side effects.
Treatment: symptomatic.
Interaction:Possible disruption of absorption of bisphosphonates with simultaneous ingestion with agents,containing aluminum, calcium, iron, magnesium, including antacids, mineral supplements, some osmotic laxatives.
With the simultaneous use of bisphosphonates and aminoglycosides, additive hypocalcemia is possible.
Special instructions:With Paget's disease every 3-6 months, the activity of alkaline phosphatase, the concentration of hydroxyproline in the urine, before the treatment and 4 weeks after it determine the content of phosphates in the blood. With hypercalcemia control the content of albumin, calcium. With Paget's disease and hypercalcemia, kidney function is assessed, especially the study of glomerular filtration and determination of urea concentration.
Patients taking etidronic acid should receive a sufficient amount of calcium and vitamin D.