Ethosuximide - instructions for use, dose, side effects, contraindications

Clinical and pharmacological group: & nbsp

Antiepileptic agents

Included in the formulation

Suxilep

capsules inwards

Miebe GmbH Artsclimitel

Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):

VED

ONLS

АТХ:

N.03.A.D Derivatives of succinimide

N.03.A.D.01 Ethosuximide

Pharmacodynamics:

Pharmacological action - anticonvulsant, miorelaksiruyuschee, analgesic.

Oppresses synaptic transmission in the motor zones of the cerebral cortex, increases the convulsive threshold. Reduces the frequency of small seizures of epilepsy, epileptiform attacks, suppresses paroxysmal electroencephalographic activity, associated with the characteristic for absences consciousness disorders. It is also effective in myoclonic seizures.

Has analgesic effect in trigeminal neuralgia.

Pharmacokinetics:

When ingested quickly and almost completely absorbed from the digestive tract. Maximum concentrationin the blood is achieved after 1-4 hours. The therapeutic concentration is 40-100 μg / ml. Slightly binds to blood plasma proteins. Metabolised in the liver. It passes well through the histohematological barriers, including blood-brain barrier, placental barriers, penetrates into breast milk. Half-lifein adults it is 56-60 hours, in children 30-36 hours.It is excreted mainly by the kidneys (20% unchanged).

Indications:

Small epileptic seizures: pycnopletic absences, complicated or atypical convulsive seizures, myoclonic-astatic small seizures (petit mal), juvenile myoclonic seizures (impulsive small seizures).

ICD-10

VI.G40-G47.G40 Epilepsy

VI.G50-G59.G50.0 Neuralgia of the trigeminal nerve

Contraindications:

Hypersensitivity, hepatic and / or renal failure, blood diseases, porphyria.

Carefully:

Mental illness in the anamnesis.

Pregnancy and lactation:

Not recommended for use in pregnancy. For the duration of treatment, breastfeeding should be discontinued.

Dosing and Administration:

Inside. The dose is selected strictly individually, depending on the clinical picture, the patient's individual reaction to the drug and tolerability. Inside adults and children over 6 years in a dose of 15-30 mg / kg per day, if necessary, the dose is gradually increased taking into account the clinical effect, the frequency of reception 2-4 times a day. Children under the age of 6 years - 15-40 mg / kg per day, if necessary, the dose is gradually increased taking into account the clinical effect, the frequency of reception 2-4 times a day.

The maximum daily intake for adults and children over 6 years of age is 1.5 g; children under 6 years - 1 g.

Side effects:

From the side nervous system and sense organs: possible - ataxia, dyskinesia, dizziness, drowsiness, headache, irritability, fatigue, decreased concentration, aggressiveness, depression, increased tonic-clonic seizures, hallucinatory-paranoid disorders, parkinsonism.

From the side organs of the digestive tract: possible - hiccups, nausea, vomiting, loss of appetite, diarrhea / constipation.

From the side cardiovascular system and blood (hematopoiesis, hemostasis): leuko-, thrombocyto-, pancytopenia, agranulocytosis, aplastic anemia, eosinophilia are possible.

Other: possible - Stevens-Johnson syndrome, lupus-like syndrome, photophobia, albuminuria, weight loss.

Overdose:

Symptoms: fatigue, decreased physical activity, loss of interest in the environment, decreased mood, increased excitability, irritability.

Treatment: gastric lavage, reception of activated charcoal; if necessary, symptomatic therapy in a hospital. There is no specific antidote. Forced diuresis and exchange transfusion are ineffective. Hemodialysis can be effective.

Interaction:

Carbamazepine accelerates metabolism and reduces the content of ethosuximide in plasma.

With simultaneous application with valproic acid, it is possible to increase the concentration of ethosuximide and decrease the concentration of valproate in the blood plasma.

With simultaneous use with haloperidol, changes in the type and / or frequency of epileptic seizures and a significant decrease in the concentration of haloperidol in the blood plasma are possible.

When used simultaneously with carbamazepine, primidon, phenytoin, phenobarbital, the concentration of ethosuximide in the blood plasma decreases.

Alcohol and other drugs that cause CNS depression, increase the CNS depression.

Special instructions:

Do not use during work drivers of vehicles and people whose profession is associated with increased concentration of attention.

During the treatment it is necessary to completely eliminate the use of alcohol.

Instructions

Ethosuximide (Aethosuximidum)