Enzalutamide (Enzalutamide)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
Read on
Clinical and pharmacological group: & nbsp

Androgens, antiandrogens

Included in the formulation
  • Kstandy
    capsules inwards 
    Astellas Farma Europe BV     Netherlands
    • АТХ:

    L.02.B.B.04   Enzalutamide

    Pharmacodynamics:Non-steroidal antiandrogenic agent. It blocks androgen receptors of target cells, which leads to disruption of replication of malignant tumor cells of the prostate due to an obstacle to the action of endogenous androgens.
    Pharmacokinetics:

    After oral administration, it is completely absorbed in the gastrointestinal tract. The maximum concentration in the blood plasma is reached after 12 hours. The connection with plasma proteins is 84%.

    Therapeutic effect develops after the reception. Metabolism in the liver up to 5 metabolites, one of which has pharmacological activity (50% of enzalutamide).

    The half-life is 50 hours. Elimination with faeces (up to 62%) and 48% - with the kidneys.

    Indications:It is used for the purpose of palliative treatment of prostate cancer with metastases.
    ICD-10

    II.C60-C63.C61   Malignant neoplasm of prostate

    XXI.Z40-Z54.Z51.5   Palliative Care

    Contraindications:Severe hepatic insufficiency, brain tumor, epilepsy, age under 18, individual intolerance.
    Carefully:Anemia, hepatic insufficiency of mild and moderate degree.
    Pregnancy and lactation:

    Pthe drug is not used in women.

    Dosing and Administration:

    Inside, washed down with a lot of water, 160 mg once a day.

    The highest daily dose: 160 mg.

    The highest single dose: 160 mg.

    Side effects:

    Central and peripheral nervous system: headache, dizziness, insomnia, nervousness, drowsiness, weakness, depression, peripheral neuropathy.

    Respiratory system: shortness of breath, hyperventilation, respiratory tract infections.

    Hemopoietic system: leukopenia, anemia, thrombocytopenia, methemoglobinemia.

    The cardiovascular system: arterial hypertension, pastosity of the palms and soles, sensation of hot flashes.

    Digestive system: nausea, vomiting, dry mouth, constipation, flatulence, decreased appetite, bleeding from the gastrointestinal tract.

    Musculoskeletal system: pain in the distal parts of the hands and feet.

    Reproductive system: decreased libido, impotence.

    Sense organs: frustration of twilight vision, increased photosensitivity, violation of color vision, paresis accommodation.

    Allergic reactions.

    Overdose:

    Increased side effects.

    Treatment is symptomatic.

    Interaction:Strengthens the effects of propranolol, lidocaine, diazepam, theophylline, phenytoin.
    Special instructions:In the treatment of wearing sunglasses is recommended, alcohol is not used to avoid disulfiram reactions. It is not recommended to drive and work with moving machinery.
    Instructions
    Up