Included in the formulation
АТХ:C.09.C.A.10 Fimasartan
Pharmacodynamics:Angiotensin II receptor antagonist selectively binds to AT1receptors in the vessels, the adrenal cortex, the heart, the kidneys. Prevents the effect of angiotensin II on renal blood flow and blood pressure.
Does not affect the concentration in the blood plasma of low-density lipoproteins, triglycerides and glucose. Improves renal blood flow, without affecting the mechanisms of self-regulation of the kidneys. In patients with healthy kidneys, increases natriuresis and does not cause retention of sodium ions in patients with renal insufficiency.
Has hypotensive, vasodilating, nephroprotective effect, reducing the excretion of albumins, increases the rate of glomerular filtration and renal blood flow. With prolonged use suppresses the proliferation of smooth muscle vessels and myocardium, caused by angiotensin II.
Pharmacokinetics:After oral administration, an empty stomach is absorbed in the gastrointestinal tract up to 50%. The maximum concentration in the blood plasma is achieved after 0.5-1.5 hours. The connection with plasma proteins is 99.5%.
Metabolism in the liver.
The half-life is 5-8 hours. Elimination with feces.
Indications:It is used for the treatment of arterial hypertension.
IX.I10-I15.I15 Secondary Hypertension
IX.I10-I15.I10 Essential [primary] hypertension
Contraindications:Stenosis of an artery of a unique kidney, a primary aldosteronism, age till 18 years, pregnancy and a lactemia, an individual intolerance.
Carefully:Chronic renal failure, hypokalemia, hyponatremia, renovascular hypertension, advanced age, impaired liver function, chronic heart failure, hypertrophic cardiomyopathy, recently performed kidney transplantation, hypersensitivity.
Pregnancy and lactation:Recommendations for FDA - Category C in I trimester, category D in II and III trimester. It enters the breast milk, reduces lactation: it is recommended to stop breastfeeding during treatment.
Dosing and Administration:Inside, 60 mg once a day. If necessary, the dose may be increased to 120 mg.
The highest daily dose: 120 mg.
The highest single dose: 120 mg.
Side effects:Central and peripheral nervous system: headache, dizziness, asthenia.
Respiratory system: rhinitis.
The cardiovascular system: postural hypotension.
Digestive system: dyspeptic disorders, vomiting, diarrhea.
Allergic reactions.
Overdose:Arterial hypotension.
Treatment is symptomatic.
Interaction:At simultaneous application with blockers of slow calcium channels and thiazide diuretics, a mutual enhancement of hypotensive effect is observed.
When used simultaneously with non-steroidal anti-inflammatory drugs, there is a chance of developing acute renal failure.
Special instructions:When taking the drug is not recommended driving and working with moving machinery.