Levobupivacaine (Levobupivacainum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Local Anesthetics

Included in the formulation
  • Hirocain®
    solution for injections 
    EbbVi Ltd.     Russia
    • АТХ:

    N.01.B.B.10   Levobupivacaine

    Pharmacodynamics:

    Local anesthetic from the group of amides. Reduces the permeability of the membrane of neurons for sodium, potassium and calcium ions, which leads to a reversible blockade of nerve conduction. Interrupts the transmission and conduct of pulses of the cardiovascular and central nervous system.

    Pharmacokinetics:

    After intravenous administration, the maximum binding to plasma proteins is 97%.

    Therapeutic effect develops after the reception.

    The half-life for intravenous administration is 80 minutes. Elimination by the kidneys.

    Indications:

    It is used for all types of surgical interventions: epidural anesthesia, including cesarean section, intrathecal anesthesia, peripheral nerve blockade.

    Used for small operations during infiltration anesthesia, peribulbar blockade in ophthalmology.

    For relief of pain syndrome is used with prolonged epidural infusion, or for bolus epidurally during labor or after surgery.

    It is used in children for iliac inguinal or ilio-hypogastric blockade.

    ICD-10

    XVIII.R50-R69.R52   Pain, not elsewhere classified

    XXI.Z40-Z54.Z40   Prophylactic surgical intervention

    XV.O80-O84.O80.9   Single-sided spontaneous delivery, unspecified

    XXI.Z100.Z100.0 *   Anesthesiology and premedication

    XVIII.R50-R69.R52.9   Pain, unspecified

    XXI.Z100.Z100 *   CLASS XXII Surgical Practice

    Contraindications:

    Cardiogenic shock, paracervical blockade in obstetric practice, individual intolerance.

    Carefully:

    Simultaneous use with antiarrhythmic drugs, diseases of the cardiovascular and central nervous system, liver disease, hypersensitivity.

    Pregnancy and lactation:

    Recommendations for FDA - Category C. It is used with caution, in cases where the expected effect exceeds the risk for the fetus and newborn, at a dose of not more than 7.5 mg / ml.

    Dosing and Administration:

    For intravenous administration, the dose is determined individually. Epidural - 0,5% solution to enter 3-5 ml.

    Side effects:

    Central and peripheral nervous system: headache, dizziness, syncope, convulsions, paraplegia, paresthesia.

    Respiratory system: sneezing, laryngeal edema, apnea, respiratory arrest.

    Hemopoietic system: anemia.

    The cardiovascular system: arterial hypotension, face hyperemia.

    Digestive system: nausea, vomiting.

    Musculoskeletal system: pain in the back, muscle weakness, muscle twitching.

    Dermatological reactions: hives.

    Sense organs: ringing in the ears, impaired vision.

    urinary system: bladder dysfunction.

    Reproductive system: priapism, distress syndrome in the fetus.

    Allergic reactions.

    Overdose:

    Arrhythmia, hypoxia, apnea, cardiac arrest.

    Treatment is symptomatic. Introduction of thiopental (50-100 mg) or diazepam (5-10 mg) intramuscularly.

    Interaction:

    When used simultaneously with calcium channel blockers, β-blockers and antiarrhythmics, the risk of oppression of conduction and contractility of the myocardium increases.

    Strengthens the hypotensive effect of nitrates and antihypertensive agents.

    Special instructions:

    The use of the drug is not recommended for subarachnoid anesthesia.

    Instructions
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