Included in the formulation
Pharmacodynamics:Selectively binds to opioid μ-, δ- and κ-receptors. Modulates cortico-mesolimbic functions, reducing the desire drinking alcohol.
Pharmacokinetics:After ingestion, up to 41% is absorbed in the gastrointestinal tract. The maximum concentration in the blood plasma is reached after 1.5 hours. The connection with plasma proteins is 30%.
Metabolism in the liver.
The half-life is 12.5 hours. Elimination by the kidneys.
Indications:It is used for the treatment of alcohol dependence.
XXI.Z70-Z76.Z72.1 Alcohol consumption
Contraindications:Pregnancy and lactation, opioid dependence, abstinence syndrome after opioid withdrawal, severe renal and hepatic insufficiency, alcohol delirium, age under 18, individual intolerance.
Carefully:Epilepsy and convulsions in the anamnesis, moderate and mild renal and hepatic insufficiency, hypersensitivity.
Pregnancy and lactation:Recommendations for FDA - Category B. Contraindicated in pregnancy and lactation.
Dosing and Administration:Inside of the morning, 18 mg.
The highest daily dose: 18 mg.
The highest single dose: 18 mg.
Side effects:Central and peripheral nervous system: headache, dizziness, hallucinations, drowsiness, tremor, paresthesia.
The cardiovascular system: tachycardia.
Digestive system: dry mouth, nausea, vomiting, anorexia, weight loss.
Musculoskeletal system: muscle spasms.
Dermatological reactions: Hyperhidrosis.
Reproductive system: decreased or absent libido.
Allergic reactions.
Overdose:Increased side effects.
Treatment is symptomatic.
Interaction:With simultaneous use reduces the effect of opioid agonists: antitussive, anti-cold, antidiarrhoeal agents, and opioid analgesics.
Simultaneous use with alcohol does not prevent the development of alcohol intoxication.
Special instructions:When taking the drug is not recommended driving and working with moving machinery.