Benzidamine - instructions for use, dose, side effects, contraindications

It indiscriminately suppresses synthetases of prostaglandins. Suppresses the production of anti-inflammatory cytokines. Has analgesic, antipyretic and anti-inflammatory effect.It does not inhibit COX1 and COX2, which regulate the synthesis of prostaglandins, so it does not cause ulceration.

Reduces thrombosis, aggregation and adhesion of platelets, suppressing the synthesis of thromboxane A₂ in thrombocytes.

It has antibacterial action, penetrates the membranes of microorganisms, disrupts metabolic processes, damaging the lysosomes of the cell. Active with respect to Candida albicans, Gardnerella vaginalis.

Pharmacokinetics:

After oral administration, up to 90% is absorbed in the gastrointestinal tract. The maximum concentration in the blood plasma is reached after 1.5 hours. The connection with plasma proteins is 20%. It accumulates in the lesions.

Metabolism in the liver.

The half-life is 13 hours. Elimination of kidneys and feces in the form of inactive metabolites.

Indications:

It is used for the treatment of inflammatory diseases of the throat and oral cavity: pharyngitis, tonsillitis, stomatitis, glossitis, periodontitis, candidiasis. Used in the form of a solution for syringing in inflammatory diseases of the vagina in the combined treatment of trichomonias and fungal infections of the vagina.

It is applied externally with insufficient veins of the lower extremities,manifested by pastosity and edema of the feet and shins, cramps at night, paresthesias and pains, a sense of the severity of the lower limbs.

ICD-10

I.A50-A64.A59 Trichomoniasis

IX.I80-I89.I80 Phlebitis and thrombophlebitis

X.J00-J06.J02.9 Acute pharyngitis, unspecified

X.J00-J06.J03.9 Acute tonsillitis, unspecified

XI.K00-K14.K05 Gingivitis and periodontal disease

XI.K00-K14.K12 Stomatitis and related lesions

XIV.N70-N77.N76 Other inflammatory diseases of the vagina and vulva

XXI.Z100.Z100 * CLASS XXII Surgical Practice

Contraindications:

Phenylketonuria, individual intolerance, children under 12 years (for solution).

Carefully:

Hypersensitivity.

Pregnancy and lactation:

Recommendations for FDA - Category C. Contraindicated for oral administration during pregnancy and lactation.

Dosing and Administration:

Inside to 50 mg 4 times a day.

A solution for gargling 15 ml every 2-3 hours until pain is eliminated.

Aerosol for 4-8 doses every 1.5-3 hours.

Intravaginally in prone position.

Locally, the gel is applied to the affected areas 2-3 times a day.

The highest daily dose: 2 g.

The highest single dose: 50 mg.

Side effects:

Central and peripheral nervous system: sleep disorders, visual hallucinations.

The cardiovascular system: tachycardia.

Digestive system: dry mouth, nausea, vomiting, gastralgia.

Allergic reactions.

Overdose:

Increased side effects.

Treatment is symptomatic.

Interaction:

Increases the concentration in the plasma digoxin, phenytoin, lithium preparations.

Special instructions:

It can slow down the reaction rate when driving vehicles and controlling machinery.

Instructions

Benzidamine (Benzydaminum)