Included in the formulation
Pharmacodynamics:Synthetic oral hypoglycemic agent from the biguanide group.
The drug enhances anaerobic glycolysis, reduces the absorption of glucose from the gastrointestinal tract, depresses gluconeogenesis in the liver, increases the sensitivity of tissues to insulin.
Lowering the appetite, buformin causes a significant reduction in body weight in diabetic patients suffering from obesity. It also has anti-lipid and fibrinolytic action.
Pharmacokinetics:The greatest hypoglycemic effect occurs 4-5 hours after taking the drug and lasts about 8 hours. Absorption from the gastrointestinal tract is almost complete. Easily penetrates into various tissues, bypassing the histohematetic barriers. The half-life is 3-7 hours. It is excreted mainly by the kidneys.
Indications:Diabetes mellitus type 2 in adults, as part of combination therapy with sulfonylureas, insulin resistance forms of diabetes (in combination with insulin), primary and secondary resistance to sulfonylurea preparations; moderate forms of diabetes, obozrenie obesity.
IV.E65-E68.E66 Obesity
IV.E10-E14.E11 Non-insulin-dependent diabetes mellitus
Contraindications:- Hypersensitivity to buformin
- Chronic renal and hepatic impairment
- Heart and respiratory failure
- Chronic alcoholism
- Diabetic coma
- Albuminuria due to diabetic nephropathy
- Ketoacidosis
- Fever
- Pregnancy, lactation
Carefully:- Elderly age
- Therapeutic starvation
- Low body weight
Pregnancy and lactation:Contraindicated in pregnancy. If taking the drug is necessary, then breastfeeding for the period of treatment should be canceled.
Dosing and Administration:The drug is taken orally during a meal. The maximum daily dose of 300 mg is divided into 2-3 doses. For the prolonged form, the frequency of administration is 1 time per day.
When obesity is taken at 100 mg per day in combination with anorexigens.
Side effects:On the part of the organs of the gastrointestinal tract: loss of appetite, nausea, vomiting, abdominal pain, diarrhea, metallic taste in the mouth.
Other: allergic reactions (redness of the skin, skin itching), low body weight.
Overdose:Symptoms: hypoglycemic coma.
Treatment: in mild cases - immediate intake of sugar pieces, honey, sweet hot tea; in severe cases - the introduction of 50% glucose solution (50 ml intravenously and intravenously), intravenously drip 5-10% glucose solution, intramuscular glucagon injection 1-2 mg. When edema of the brain requires the introduction of mannitol and dexamethasone, monitoring the level of glycemia (every 15 minutes), the determination of ketone bodies.
Interaction:Buformin enhances and prolongs the effects of exogenous insulin. Derivatives of phenothiazine (including aminazine), tRTI ID = 0.0 & gt; hormones, estrogens, diuretics weaken the hypoglycemic effect lt; / RTI & gt;
Inhibitors of monoamine oxidase, derivatives of sulfonylureas, fromalicylates reinforce hypoglycemic effect lt; / RTI & gt;
Special instructions:During the treatment period, it is necessary to regularly examine urine for acetone and blood glucose level.