Activated carbon + Aluminum oxide - instructions for use, dose, side effects, contraindications

Clinical and pharmacological group: & nbsp

Adsorbents

Included in the formulation

Enteramin®

powder inwards

UPDATE OF PFC, CJSC Russia

АТХ:

A.07.B.A.01 Activated carbon

Pharmacodynamics:

Granular alumina coated with a carbon film. Combined drug. It shows the properties of enterosorbent, desintoxicant, antidiarrhoeal agent. Combinations are characterized by high adsorptive activity. It removes microbial cells from the gastrointestinal tract, endo- and exotoxins. Does not cause changes in acid-base and water-electrolyte equilibrium, promotes the excretion of heavy metals. It does not bind hydrogen sulphide, which is normal in the lumen of the intestine and is necessary for maintaining normal peristalsis. The most effective for controlling intoxication medium- and high-molecular substances).

Pharmacokinetics:

Of aluminum oxide, which is part of the combination, before the absorption is formed aluminum chloride, which is absorbed by 15-30%. Elimination of the absorbed part is carried out by the kidneys, the other part is excreted with feces. The average enterosorption time of activated carbon is 23.5 hours. It is not absorbed into the blood. It is not metabolized. Elimination with faeces for 24-48 hours.

Indications:

- intestinal infections;

- purulent-septic diseases;

- hepatic and / or renal insufficiency;

- hepatitis;

- allergic diseases;

- metabolic disorders;

- burn disease;

- abstinent alcohol syndrome.

ICD-10

I.A00-A09.A02.9 Salmonella infection, unspecified

I.A00-A09.A05.9 Bacterial food poisoning, unspecified

I.A00-A09.A09 Diarrhea and gastroenteritis of allegedly infectious origin

I.B15-B19.B18.9 Chronic viral hepatitis, unspecified

I.B15-B19.B19 Viral hepatitis, unspecified

IV.E70-E90.E80.6 Other disorders of bilirubin metabolism

V.F10-F19.F10.3 Mental and behavioral disorders caused by alcohol use - withdrawal symptoms

XI.K20-K31.K30 Dyspepsia

XI.K55-K63.K59.1 Functional diarrhea

XI.K70-K77.K74.6 Other and unspecified liver cirrhosis

XVIII.R90-R94.R93.3 The abnormalities detected in obtaining a diagnostic image during the examination of other parts of the digestive tract

XIV.N17-N19.N18 Chronic Renal Failure

XVIII.R10-R19.R14 Meteorism and related conditions

XIX.T20-T32.T30 Thermal and chemical burns, unspecified

XIX.T36-T50.T46.0 Poisoning with cardiac glycosides and preparations of similar action

XIX.T51-T65.T56 Toxicity of metals

XIX.T66-T78.T78.4 Allergy, unspecified

Contraindications:

- hypersensitivity to the drug;

- intestinal obstruction;

- bleeding from the digestive tract.

Carefully:

Alzheimer's disease, appendicitis or suspicion of it, bleeding - gastrointestinal, rectal or unspecified localization, ulcerative colitis, colostomy, diverticulitis, ileostomy, constipation, chronic diarrhea, obstruction of the outlet stomach, hypophosphatemia, severe renal dysfunction, chronic renal failure, children's age, breast-feeding.

Pregnancy and lactation:

The category of FDA recommendations is not defined. The use of antacids and aluminum-based sorbents is considered safe, except for long-term use in large doses. Adequate and well-controlled studies in pregnant women have not been conducted. Information has been published on cases of hypercalcemia, hypomagnesemia, hypermagnesia, as well as on the increase of tendon reflexes in the fetus and / or newborns whose mothers have taken aluminum, calcium or magnesium preparations, especially long and in large doses. Animal studies were not conducted.

There is no information on the penetration into breast milk. Complications are not registered. Despite the fact that aluminum, calcium and magnesium-containing antacids are able to penetrate into the milk, their concentration is not enough to have an effect in the child.

Dosing and Administration:

Inside, 1-1.5 hours before or 1 hour after eating or taking medicines, diluted with boiled water or 2% starch slime in a ratio of 1: 4. The daily dose is 1 g / kg (adults - 50-75 g, children - 6-50 g) in 3 divided doses. The course of treatment is 3-14 days.

In case of acute poisoning after washing the stomach, 100-150 g per reception is prescribed, mixed with water in a ratio of 1: 4 or with a 1: 1 vaseline oil.

The course of treatment is 3-14 days.

Application in elderly patients

Not studied systematically, individual studies report safety of use in a standard dosage for the elderly.

Use in children

Limited due to a lack of adequate controlled studies.

Side effects:

Neurotoxicity, constipation, osteomalacia, osteoporosis, phosphate deficiency syndrome, allergic reactions.

Overdose:

Not described. Treatment is symptomatic.

Interaction:

Combination activated carbon + aluminum oxide can reduce the effectiveness of concomitant medications. Preparations are absorbed in the intestines and their absorption into the systemic blood flow is reduced.

Special instructions:

Common to all antacids.

With impaired renal function, regular monitoring of the concentrations of Mg2 +, Ca2 +, Al3 +, and phosphorus is required. It is necessary to avoid prolonged use of the drug in high doses.

With prolonged use, sufficient intake of phosphorus is required.

It releases from the gastrointestinal tract endo- and exotoxins of various origin.

Does not cause changes in water-electrolyte metabolism, promotes the excretion of heavy metals, does not absorb in the intestine the hydrogen sulphide needed to maintain normal peristalsis.

On the therapeutic effect is not inferior to lignin hydrolyzed, carboline (more effective in diseases accompanied by intoxication medium- and high-molecular substances).

Stains fecal masses black.

Storage of the drug in air reduces sorption capacity.

Instructions

Activated carbon + Aluminum oxide (Carbo activatus + Aluminii oxydum)