Algeoldrate - instructions for use, dose, side effects, contraindications

Clinical and pharmacological group: & nbsp

Antacids

Included in the formulation

Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):

ONLS

VED

АТХ:

A.02.A Antacids

Pharmacodynamics:

Neutralizes hydrochloric acid of gastric juice, which is why it increases pH in the stomach and the activity of pepsin decreases. Wherein algebra does not change the production of hydrochloric acid. The drug rendersTotal protective effect:

- binds mucosal damaging agents (bile acids, cytotoxins, lysolecithin);

- stimulates protective factors (activation of the synthesis of prostaglandins and glycoproteins, stimulation of bicarbonate secretion and protective mucopolysaccharide mucus).

Pharmacokinetics:

Absorption is low. 15-30% of the formed aluminum chloride is absorbed into the blood and excreted by the kidneys. The remaining aluminum salts are eliminated through the gastrointestinal tract.

Indications:

It is used in conditions accompanied by high acidity, in the treatment of various diseases of the digestive and as part of complex therapy.

ICD-10

XI.K20-K31.K20 Esophagitis

XI.K20-K31.K21.0 Gastroesophageal reflux with esophagitis

XI.K20-K31.K25 Stomach ulcer

XI.K20-K31.K26 Duodenal ulcer

XI.K20-K31.K29 Gastritis and duodenitis

XI.K20-K31.K29.6 Other gastritis

XI.K20-K31.K29.8 Duodenitis

XI.K20-K31.K30 Dyspepsia

XI.K40-K46.K44 Diaphragmatic hernia

XI.K50-K52.K52.8 Other specified non-infectious gastroenteritis and colitis

XI.K80-K87.K85 Acute pancreatitis

XVIII.R10-R19.R10.1 Pain localized in the upper abdomen

XVIII.R10-R19.R12 Heartburn

Contraindications:

Hypersensitivity to aluminum; kidney failure; pregnancy; Alzheimer's disease; increased concentration of aluminum in the blood; hypophosphatemia; intestinal obstruction, constipation.

Use in children: efficacy and safety not studied.

Carefully:

Appendicitis, bleeding from the digestive tract, ulcerative colitis, chronic diarrhea, diverticulitis, colostomy, ileostomy, kidney disease, lactation.

Pregnancy and lactation:

This drug is not classified FDA. The use of antacids is considered safe, except for prolonged use in large doses. Adequate and well-controlled studies have not been performed in humans, but there are data on such side effects of antacids as hypercalcemia, hypomagnesemia, hypermagnesia, as well as an increase in tendon reflexes in the fetus and / or newborns whose mothers took long-term aluminum, calcium or magnesium-containing antacids , especially in high doses. Animal studies were not conducted. Complications in women during lactation are not registered.Despite the fact that aluminum, calcium and magnesium-containing antacids are able to penetrate into the milk, their concentrations are not enough to have an effect on the newborn.

Dosing and Administration:

Take 5-10 ml of oral suspension (minimum dose), if necessary up to 15 ml. Duration of admission - up to 6 weeks before the disappearance of all symptoms.

With diseases of the esophagus, stomach and duodenum - take algebra follows after eating, with bowel disease - before meals. To alleviate the pain syndrome, additional doses of the algalodrat may be taken between the basic methods.

Patients with disorders such as duodenal ulcer, Zollinger-Ellison syndrome, multiple endocrine adenoma and systemic mastocytosis, a dose up to 30-60 ml of any algebra (maximum dose).

Aluminum hydroxide, which is the basis of the algebra, gets into the intestines and binds to the residues of phosphoric acid, forming insoluble aluminum salts, which are extracted from the digestive tract. Deficiency of phosphates in the blood plasma, due to the difficulty of their absorption, leads to an increase in the release of calcium from the bones.In this regard, in the case of long reception, as well as taking in maximum doses up to two weeks, a doctor's consultation is necessary.

Side effects:

From the digestive system: constipation, changes in taste, nausea, vomiting, diarrhea.

From the laboratory indicators: with prolonged use in high doses - an increase in the concentration of aluminum in the blood, hypophosphatemia, hypocalcemia.

From the urinary system: kidney failure; with prolonged admission in high doses - hypercalciuria, renal dysfunction, nephrocalcinosis. When taking on a background of kidney failure, it is possible to lower blood pressure, thirst, hyporeflexia.

Other: at long reception in high doses encephalopathy, an osteoporosis, an osteomalacia, allergic reactions are possible.

Overdose:

Symptoms - constipation, treatment - laxatives. With a chronic overdose, Newcastle bone disease develops: hypophosphatemia, aluminum encephalopathy, kidney failure.

Interaction:

Amphetamines, quinidine in doses, alkalinizing urine, - algebra can inhibit their renal excretion and thereby increase their toxicity; it is necessary to adjust the dose with the simultaneous administration of these drugs with the algebra, the withdrawal of the alginate or changing its dose.

Blockers H₂-receptor histamine - algebra reduces their absorption, when taken in medium or high doses (80-150 mmol); the recommended interval between prescribing drugs is not less than 0.5-1 h.

Vitamins of the group D, including calcipediol and calcitriol, - possible gipermagniyemiya, especially in patients with chronic kidney disease.

Ketoconazole - algebra reduces absorption by increasing gastrointestinal pH; take the algebra should not be earlier than 3 hours after taking ketoconazole.

Mekamylamine - reduces the rate of absorption and prolongs the effect; simultaneous reception is not recommended.

Methenamine - algebra reduces effectiveness; simultaneous appointment is not recommended.

Sodium fluoride - the formation of complexes with an algebra, in this regard, decreases absorption.

Pancreolipase - reduces the effectiveness of the drug, do not recommend the simultaneous administration of these drugs.

Preparations of iron for oral administration - reduced effectiveness, must be taken at different times.

Salicylates - algebra increases their renal excretion, it is necessary to adjust the dose of salicylates with long-term admission of the alginate, or it is necessary to cancel algebra at the time of taking salicylates, especially at high dosages of the latter (with rheumatoid arthritis, rheumatic fever).

Special instructions:

The dose of algalodrat needed to neutralize the hydrochloric acid of gastric juice varies in different patients. It depends on the amount of secreted hydrochloric acid and buffer capacity of the algebra (per 1 mole of hydrochloric acid 15-20 moles of aluminum hydroxide).

There is information about an increase in the level of secretion of gastrin in the appointment of antacids.

In chronic kidney diseases, control of phosphate concentrations and Al³⁺. It is necessary to avoid high doses and long reception. In patients with renal insufficiency against the background of the use of an algebra, thirst, a decrease in blood pressure, hyporeflexia are possible.

Do not use in patients with high concentrations of aluminum in the blood (a risk factor for developing or worsening the course of Alzheimer's disease), as well as with constipation.

It is not recommended to take alginate in large doses for longer than two weeks without consulting a doctor.

The absorption of aluminum increases with the simultaneous intake of acidic drinks (fruit juices, wine).

Instructions

Algeldrat (Algeldratum)