Included in the formulation
АТХ:R.05.D.A Opium alkaloids and its derivatives
Pharmacodynamics:Guaifenesin
Increases the activity of ciliated epithelium, increases the secretion of liquid components of bronchial mucus due to depolymerization of acidic polysaccharides. Increases the volume of sputum, reducing its viscosity, facilitating its evacuation from the respiratory tract.
Dextromethorphan
Disomer of levorphanol, is close to codeine, but does not exert a depressant effect on the respiratory center and the activity of the ciliary epithelium. Has no analgesic effect.
Reduces the intensity of dry cough due to an increase in the cough threshold due to the suppression of afferent impulses from the mucous membrane of the respiratory tract.
Pharmacokinetics:Guaifenesin
After oral administration, it is rapidly absorbed in the gastrointestinal tract. The maximum concentration in the blood plasma is reached after 25-30 minutes. Metabolism in the liver with the formation of the main metabolite - β- (2-methoxyphenoxy) lactic acid. The elimination half-life is 1 hour. Elimination by the kidneys.
Dextromethorphan
The therapeutic effect develops 15-30 minutes after the beginning of the admission.Metabolism in the liver by glucuronization, O-demethylation and N-Demitization. It is excreted mainly by the kidneys in unchanged form and in the form of metabolites.
Indications:It is used as a symptomatic antitussive for catarrhal diseases, acute respiratory infections, influenza.
X.J00-J06.J06.9 Acute upper respiratory tract infection, unspecified
X.J10-J18.J10 Influenza caused by an identified influenza virus
XVIII.R00-R09.R05 Cough
Contraindications:Organic damage to the central nervous system, peptic ulcer of the stomach and duodenum, gastric bleeding, including in the history, individual intolerance, children under 6 years.
Carefully:Hepatic and renal insufficiency, bronchial asthma.
Pregnancy and lactation:Recommendations for FDA - Category C. Contraindicated in pregnancy and lactation.
Dosing and Administration:Children 6-12 years: 1 teaspoon every 4 hours.
Adults and children over 12 years: 2 teaspoons every 4 hours.
Side effects:Central and peripheral nervous system: headache, dizziness, drowsiness. Increased excitability in children.
Digestive system: gastralgia, nausea, vomiting, diarrhea.
Allergic reactions.
Overdose:Guaifenesin
Nausea, vomiting.
Dextromethorphan
Dizziness, impaired consciousness, hypotension, tachycardia, ataxia.
Treatment is symptomatic.
Interaction:Compatible with antibiotics, cardiac glycosides, bronchodilators.
Simultaneous use with monoamine oxidase inhibitors, including procarbazine, selegiline, furazolidone, can cause an increase in blood pressure, collapse, adrenergic crisis, hyperpyrexia, intracranial hemorrhage, to whom.
Amiodarone, quinidine, fluoxetine: increase the concentration of the drug in the blood by inhibiting cytochrome P450.
Increases the effect of drugs that depress the central nervous system, as well as ethanol.
Special instructions:It is recommended to take a sufficient amount of liquid during treatment. Reception of guaifenesin is often accompanied by urine staining in pink.
When treating the drug should refrain from driving the car and working with moving mechanisms.