Included in the formulation
АТХ:G.03.X.A.02 Gestrinone
Pharmacodynamics:The derivative of 19-nortestosterone, inhibits the release of luteotropic and follicle-stimulating hormone, preserving their basal secretion. Competitively inhibits progesterone and androgen receptors, displacing testosterone, associated with globulin. As a result, the level of free testosterone rises. It has an androgenic and antiprogestronic action, which suppresses proliferation and causes atrophy of the endometrium and ectopic foci of endometriosis.
Pharmacokinetics:After ingestion with food completely absorbed in the gastrointestinal tract. The maximum concentration in the blood plasma is achieved after 3 hours.
Metabolism in the liver.
The half-life is 24 hours. Elimination by the kidneys and with feces.
Indications:It is used for the treatment of genital and extragenital endometriosis.
XIV.N80-N98.N80 Endometriosis
Contraindications:Acute congestive heart failure, porphyria, severe renal and hepatic insufficiency, androgen-dependent tumors, bleeding from the genital tract of unknown origin, individual intolerance.
Carefully:Migraine, hypersensitivity.
Pregnancy and lactation:Recommendations for FDA - Category C.Contraindicated in pregnancy and lactation.
Dosing and Administration:Inside, during a meal, 2.5 mg on the 1 st and 4 th day of the menstrual cycle, then in that the same dose 2 times a week for 6 months.
The highest daily dose: 2.5 mg.
The highest single dose: 2.5 mg.
Side effects:Central and peripheral nervous system: headache, irritability, depression, convulsions.
Digestive system: nausea, vomiting.
Dermatological reactions: acne, skin pigmentation, hypertrichosis, seborrhea.
Sense organs: lowering the voice of the voice.
Urinary system: fluid retention.
Reproductive system: decreased libido.
Allergic reactions.
Overdose:Cases of overdose are not described.
Treatment is symptomatic.
Interaction:Anticonvulsants and rifampicin accelerate metabolism.
Special instructions:If you miss several doses (two or more), stop taking the drug until the next day of the menstrual cycle.