Alimamazine - instructions for use, dose, side effects, contraindications

Clinical and pharmacological group: & nbsp

Neuroleptics

Included in the formulation

Terialgen®

pills inwards

VALENTA PHARM, PAO Russia

Terialgen®

solution w / m d / infusion

VALENTA PHARM, PAO Russia

Terialgen® Valenta

pills inwards

VALENTA PHARM, PAO Russia

АТХ:

R.06.A.D. Phenothiazine derivatives

R.06.A.D.01 Alimemazine

Pharmacodynamics:

Competitive blockade H₁-receptors of effector cells, prevention (but not elimination) of effects mediated by histamine. Blockade of M-cholinergic receptors, α-adrenoreceptors.

Has a number of effects:

- fromedible, sleeping, antipsychotic, hypothermic, elimination of dizziness;

- antiemetic (action on the chemoreceptor trigger zone of the medulla oblongata);

- warning and stopping hiccups;

- prevention, but not elimination of the effects mediated by histamine (including urticaria and itching).

The duration of the action is 3-6 hours.

Pharmacokinetics:

Absorption is good. Penetrates through the placenta and GEB. The connection with plasma proteins is 65-90%. Biotransformation in the liver. The half-life is 4.4-18 (an average of 6.8) h. It is excreted by the kidneys in the form of metabolites.

Indications:

Neurotic, neurosis-like and psychopathic conditions, anxiety-depressive state (within the framework of borderline endogenous and vascular diseases), insomnia of various genesis; allergic reactions (symptomatic treatment).

ICD-10

V.F30-F39.F32 Depressive episode

V.F30-F39.F33 Recurrent depressive disorder

V.F40-F48.F40 Phobic anxiety disorders

V.F40-F48.F41.2 Mixed anxiety and depressive disorder

V.F40-F48.F43 Reaction to severe stress and adaptation disorders

V.F40-F48.F45.3 Somatoform dysfunction of the autonomic nervous system

V.F40-F48.F48 Other neurotic disorders

V.F50-F59.F51.2 Sleep and wakefulness disorder inorganic etiology

Contraindications:

Individual intolerance; angle-closure glaucoma; hyperplasia of the prostate; severe hepatic and / or renal insufficiency; Parkinsonism, myasthenia gravis, Reye's syndrome; simultaneous use of MAO inhibitors; pregnancy and lactation.

Carefully:

Alcoholism (history of complications with phenothiazine series), bladder neck obstruction, urinary retention predisposition, epilepsy, open-angle glaucoma, jaundice, suppression of bone marrow function, arterial hypotension.

Pregnancy and lactation:

Contraindicated taking the drug during pregnancy and during breastfeeding.

Dosing and Administration:

In adults - inside, intramuscularly and intravenously.The daily dose is divided into 3-4 doses. Inside 5-10 mg / day (anxiolytic effect), 60-80 mg / day (hypnotic effect). At psychotic conditions - 0,2-0,4 g / day. Intravenously, the initial dose is 0.025 g, gradually increasing to 0.075-0.1 g.

In children with urticaria and pruritis - inside:

- 6 months - 2 years - 250 mkg / kg (maximum 2.5 mg) 3-4 times a day, strictly under the supervision of a specialist;

- 2-5 years - 2.5 mg 3-4 times a day;

- 5-12 years - 5 mg 3-4 times a day;

- 12-18 years - 10 mg 2-3 times a day, in severe cases up to 100 mg / day.

For premedication of children 2-7 years: inside 2 mg / kg (maximum 60 mg) 1-2 hours before the operation.

Side effects:

Nervous system: drowsiness, restlessness, dizziness, tinnitus, paradoxical reaction (nightmares, unusual excitement, nervousness, irritability), increased convulsive activity (in children), increased sleep apnea, respiratory depression, weakness. And also catatonic-like syndrome, disorientation, extrapyramidal disorders, convulsions, hallucinations, hysteria.

Digestive system: anesthesia of the oral mucosa, dry mouth, nose, throat, loss of appetite, nausea, vomiting, cholestasis, constipation, jaundice, increased tongue.

Cardiovascular system: hypo-, hypertension, tachycardia.

Blood system: leukopenia, aplastic anemia, thrombocytopenia, agranulocytosis, malignant neutropenia, thrombocytopenic purpura.

Allergic reactions: urticaria, dermatitis, asthma, angioedema.

Skin: photosensitization, increased sweating.

Body of vision: disruption of accommodation and vision, paralysis of the eye, difficult or painful urination; noise, ringing in the ears, hearing loss.

Others: amenorrhea, gynecomastia, hyper-, hypoglycemia.

Overdose:

It appears increased adverse reactions, oppression of consciousness, symptomatic treatment.

Interaction:

Beta-adrenoblockers - increase (mutually) in plasma concentrations, severe arterial hypotension, arrhythmias, irreversible retinopathy, tardive dyskinesia.

Analgesics, hypnotics, tranquilizers, antipsychotics, anesthetics, local anesthetics, M-holinoblokatory, hypotensive drugs, other means that depress respiration, - intensifying effects, correction of doses is required.

Barbiturates - acceleration of elimination and decrease in activity of alimamazine.

Bromocriptine - weakening of its action, increasing serum prolactin concentration.

Hepatotoxic agents - increased hepatotoxicity.

MAO inhibitors (concurrent use is not recommended), phenothiazine derivatives - increased risk of developing arterial hypotension and extrapyramidal disorders.

Ototoxic agents - enhancement of ototoxicity.

Derivatives of amphetamine, M-cholinomimetics, anticholinesterase drugs, ephedrine, guanethidine, levodopa, dopamine - weakening of their action.

Riboflavin - an increase in the dose of riboflavin is necessary.

Means that depress the appetite - decrease in anorexigensal effect.

Tricyclic antidepressants, anticholinergics - enhancing M-cholinoblocking activity.

Quinidine - increased likelihood of cardiodepressive action.

Epinephrine - blockade of α-adrenergic effect, risk of serious hypotension.

Ethanol, clonidine, anticonvulsants - increased oppression of the central nervous system.

Special instructions:

The composition of the solution for infusions includes sulfites, in rare cases, intensifying anaphylactic reactions.

It is not recommended to use in children under the age of 1 if there are complications in the history of the use of phenothiazine series drugs.

During the treatment is not recommended the use of alcohol.

Instructions

Alimemazine (Alimemazinum)