Clinical and pharmacological group: & nbsp
Antacids
Included in the formulation
АТХ:A.02.A.D.04 Hydrotalcite
Pharmacodynamics:The hydrotalcite has a stratified-mesh structure with a low content of aluminum and magnesium. The release of aluminum and magnesium ions occurs gradually depending on the pH of the gastric juice. The drug provides a fast and long-lasting neutralization of hydrochloric acid with maintaining the pH close to normal. Has a protective effect on the mucous membrane of the stomach. Reduces the proteolytic activity of pepsin, binds bile acids.
Pharmacokinetics:The release of magnesium and aluminum ions occurs in the stomach gradually, depending on the pH value. Absorbed hydrotalcite in the small intestine. After ingestion, the content of magnesium and aluminum ions in the blood plasma temporarily increases, but no penetration into the nerve and bone tissue occurs (with normal kidney function). The absorbed part is excreted by the kidneys.
Indications:Giperacidnost gastric juice; heartburn; gastritis; peptic ulcer of the stomach and duodenum; reflux esophagitis.
XI.K20-K31.K21.0 Gastroesophageal reflux with esophagitis
XI.K20-K31.K25 Stomach ulcer
XI.K20-K31.K26 Duodenal ulcer
XI.K20-K31.K27 Peptic ulcer of unspecified site
XI.K20-K31.K29 Gastritis and duodenitis
XVIII.R10-R19.R12 Heartburn
Contraindications:Individual hypersensitivity to the components of the drug; children's age (up to 6 years).
Carefully:Chronic renal failure, hypophosphatemia.
Pregnancy and lactation:There is no confirmed data on the undesirable effects of hydrotalcite during pregnancy and breastfeeding.
The use of the drug during pregnancy is permitted in the event that the potential benefit to the mother exceeds the possible risk to the fetus.
The drug does not penetrate into breast milk, so its use is possible during breastfeeding.
Dosing and Administration:Inside, thoroughly chewing.
Adults and children over 12 years of age: 1-2 tablets 1 hour after meals 3-4 times a day and at bedtime.
Children from 6 to 12 years: 1 tablet 2 times a day.
Treatment should continue for 4 weeks.
Side effects:When applying the drug at recommended doses, undesirable effects occur rarely.
Allergic reactions, diarrhea, eructation are possible.
Overdose:There is no data on hydrotalcite overdose.
Interaction:Like other antacids, hydrotalcite can reduce the absorption of tetracyclines, quinolones (ciprofloxacin, ofloxacin), iron preparations and coumarins, antibiotics.
Special instructions:Interval between drug use and other drugs should be at least 1-2 hours.
It is not recommended to use the drug simultaneously with acid-containing beverages (juices, wine).
A drug does not contain sucrose, so it can be taken by patients with diabetes mellitus.
Polyols (mannitol) can cause diarrhea.
Impact on the ability to drive vehicles and manage mechanisms
A drug does not affect the ability to manage motor vehicles and other complex technical devices that require concentration of attention and speed of psychomotor reactions.