Glatiramer acetate (Glatirameri acetas)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Immunomodulators

Included in the formulation
  • Axoglatiran® ​​FS
    solution PC 
    NATIVA, LLC     Russia
  • Glatirate
    solution PC 
    R-PHARM, CJSC     Russia
  • Copaxone®-Teva
    solution PC 
    Teva Pharmaceutical Enterprises Co., Ltd.     Israel
  • Copaxone® 40
    solution PC 
    Teva Pharmaceutical Enterprises Co., Ltd.     Israel
  • Timexon®
    solution PC 
    BIOCAD, CJSC     Russia
    • Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):

    VED

    7 nosologies

    АТХ:

    L.03.A.X.13   Glatiramer acetate

    Pharmacodynamics:

    On the surface of antigen-presenting cells, competitively displaces the myelin antigens: proteolipid protein, the main protein myelin, myelin oligodendrocyte glycoprotein. Due to this, it inhibits the production of effector T-lymphocytes and stimulates antigen-specific suppressor T-lymphocytes, which leads to a reduction in local inflammation. Due to the blockade myelin-specific autoimmune reactions stops the process of destruction of myelin sheaths of nerve fibers. Has a neuroprotective effect.

    Pharmacokinetics:

    After subcutaneous administration, it undergoes local hydrolysis. Has therapeutic effect in places of administration.

    Indications:

    It is used for the treatment of multiple sclerosis remittent flow.

    ICD-10

    VI.G35-G37.G35   Multiple sclerosis

    Contraindications:

    Age to 18 years, individual intolerance.

    Carefully:

    Pregnancy and lactation, hypersensitivity.

    Pregnancy and lactation:

    Recommendations for FDA - Category B. It is used with caution during pregnancy and lactation in cases where the intended benefit exceeds the risk to the fetus and newborn.

    Dosing and Administration:

    Subcutaneously, 20 mg once a day for a long time.

    The highest daily dose: 20 mg.

    The highest single dose: 20 mg.

    Side effects:

    Central and peripheral nervous system: migraine, asthenia, tremor, anxiety, syncope, depression, rarely - suicidal tendencies.

    Respiratory system: flu-like syndrome, laryngospasm, dyspnea, bronchitis.

    Hemopoietic system: rarely - lymphadenopathy, splenomegaly.

    The cardiovascular system: tachycardia, palpitation, arrhythmia, arterial hypertension, varicose veins.

    Digestive system: decreased appetite, difficulty swallowing, nausea, vomiting, diarrhea, weight loss.

    Musculoskeletal system: arthralgia, back pain.

    Dermatological reactions: rash, hyperhidrosis, lymphadenopathy.

    Sense organs: Nystagmus, impaired vision.

    Urinary system: hematuria, peripheral edema.

    Reproductive system: amenorrhea, dysmenorrhea, metrorrhagia, impotence.

    Local Reactions: soreness in the injection site, atrophy of the skin at the injection site with prolonged use.

    Allergic reactions.

    Overdose:

    Cases of overdose are not described.

    Treatment is symptomatic.

    Interaction:

    Compatible with glucocorticoids.

    Special instructions:

    It is recommended to alternate injection sites in different parts of the body: arms, legs, abdomen.

    Instructions
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