Glutathione (Glutathionum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
Read on
Clinical and pharmacological group: & nbsp

Antihypoxants and antioxidants

Included in the formulation
  • Glathion
    powder w / m in / in 
    FARMLYUKS LLC     Russia
    • АТХ:

    V.03.A.B   Antidotes

    Pharmacodynamics:

    Tripeptide with a sulfhydryl group, consisting of L-glutamine, glycine and L-cysteine. Conjugates with xenobiotics or their toxic metabolites, increases their hydrophilicity and reduces toxicity. Restores organic peroxides to alcohols, binds free radicals. Linking to lipophilic compounds, prevents their penetration through membranes.

    Increases the activity of liver enzymes, enhancing its detoxification and restorative activity.

    Pharmacokinetics:After intravenous administration, the maximum concentration in the blood plasma is reached after 15 minutes.

    The half-life is 10 minutes. Elimination of the kidneys in the form of cysteine ​​and unchanged.

    Indications:It is used in the complex treatment of fibrosis, cirrhosis, fatty liver, hepatic encephalopathy, withdrawal syndrome. Used to reduce the hepatotoxicity of chemotherapeutic, anticonvulsant, psychotropic, hormonal drugs, as well as remedies for the treatment of gout.

    ICD-10

    I.B15-B19.B17.1   Acute hepatitis C

    I.B15-B19.B16   Acute hepatitis B

    I.B15-B19.B15   Acute hepatitis A

    I.B15-B19.B18.2   Chronic viral hepatitis C

    I.B15-B19.B18.1   Chronic viral hepatitis B without delta-agent

    XI.K70-K77.K70   Alcoholic liver disease

    XI.K70-K77.K71   Toxic liver disease

    XI.K70-K77.K74   Fibrosis and cirrhosis of the liver

    I.B15-B19.B18   Chronic viral hepatitis

    Contraindications:Individual intolerance, children's age.

    Carefully:Elderly age, hypersensitivity.

    Pregnancy and lactation:Recommendations for FDA - Category C. It is used with caution during pregnancy and lactation in cases where the intended benefit exceeds the risk to the fetus and newborn.

    Dosing and Administration:

    Intravenous (drip slowly) or intramuscularly, in a 0.9% solution of sodium chloride, 1.2-2.4 g once a day.

    The highest daily dose: 2.4 g for intravenous administration, 0.6 g when administered intramuscularly.

    The highest single dose: 2.4 g for intravenous administration, 0.6 g when administered intramuscularly.

    Side effects:The cardiovascular system: arterial hypotension, decrease or increase in heart rate.

    Digestive system: dyspeptic phenomena.

    Allergic reactions.

    Overdose:Cases of overdose are not described.

    Treatment is symptomatic.

    Interaction:Pharmacologically incompatible with tetracyclines, sulfonamides, cyanocobalamin,maleadione sodium bisulfite.

    Special instructions:

    After drug cancellation, side effects disappear.

    Instructions
    Up