Included in the formulation
Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):VED
ONLS
АТХ:G.03.G.A.01 Gonadotropin chorionic
Pharmacodynamics:Has an effect similar to the luteinizing hormone of the pituitary gland. Selectively interacts with gonadal receptors, stimulates ovulation and spermatogenesis, increases the amount of progesterone and androgens.
Pharmacokinetics:After intramuscular injection, the maximum concentration in the blood plasma is reached after 1 hour.
Metabolism in the liver.
The half-life is 8 hours. Elimination by the kidneys.
Indications:It is used in women to treat infertility, induction of ovulation, improve the function of the yellow body. In men - with cryptorchidism, delayed puberty, hypogonadotropic hypogonadism.
IV.E20-E35.E23.0 Hypopituitarism
IV.E20-E35.E28 Dysfunction of the ovaries
IV.E20-E35.E30.0 Delayed puberty
XIV.N80-N98.N97 Female infertility
XVII.Q50-Q56.Q53.9 Non-admission of testicles, unspecified
Contraindications:
Age to 4 years, hypertrophy of the pituitary gland, bronchial asthma, migraine, epilepsy, renal and hepatic insufficiency, prostate cancer, pregnancy and lactation, individual intolerance.
Carefully:
Polycystic ovary.
Pregnancy and lactation:
Recommendations for FDA - Category C. Contraindicated in pregnancy and lactation.
Dosing and Administration:
Intramuscularly. Dosage is selected individually, depending on the patient's sex and diagnosis.
For the induction of ovulation - 5-10 thousand IU a day after the end of the administration of menotropin or urofollitropina, or 5-9 days after taking clomiphene.
If the body is deficient - 1,500 IU per day, starting from the day of ovulation to the date of the expected monthly.
With hypogonadism - for 1-4 thousand IU 2-3 times a week.
With cryptorchidism - 1-5 thousand IU 2-3 times a week at prepubertal age; for 2 thousand IU once a day for 3 days - in adolescence.
Side effects:Central and peripheral nervous system: headache, anxiety, depression, weakness, irritability.
Respiratory system: dyspnoea.
Dermatological reactions: acne.
The cardiovascular system: peripheral edema.
Reproductive system: ovarian hyperstimulation syndrome, multiple pregnancy; in men - premature puberty and closure of the epiphyses, atrophy of the spermatic cord, an increase in the testicles in the inguinal canal.
Allergic reactions.
Overdose:Ovarian hyperstimulation syndrome: pain in the groin and lower abdomen, vomiting, diarrhea, decreased diuresis, swelling of the lower extremities, thickening of the blood, leading to ascites, hydrothorax, acute pulmonary insufficiency, thromboembolism.
Treatment is symptomatic.
Interaction:
Clinically significant interactions are not described.
Special instructions:It is inadmissible to increase the dose and duration of treatment, as antibodies are produced on chorionic gonadotropin, which reduces the effectiveness of the drug.