Included in the formulation
АТХ:A.04.A.A.02 Granizetron
Pharmacodynamics:
Selective blocks 5-HT(hydroxytryptamine)-receptors located in the trigger zone of the bottom IV the ventricle of the brain and the endings of the vagus nerve, due to which it has a pronounced antiemetic effect.
Does not affect the synthesis of aldosterone and prolactin.
Pharmacokinetics:After oral administration, it is completely absorbed in the gastrointestinal tract. After the initial passage through the liver, bioavailability is reduced to 60%. The connection with plasma proteins is 65%.
Metabolism in the liver.
The elimination half-life is 9 hours. Elimination with feces and kidneys.
Indications:It is used for the prevention and treatment of vomiting during chemotherapy, as well as in the postoperative period.
XVIII.R10-R19.R11 Nausea and vomiting
XXI.Z100.Z100 * CLASS XXII Surgical Practice
XX.Y85-Y89.Y88.0 Consequences of adverse effects of medicinal products, medicines and biological substances used for therapeutic purposes
XXI.Z40-Z54.Z51.0 Radiotherapy course (supportive)
XXI.Z40-Z54.Z51.1 Chemotherapy for neoplasm
Contraindications:
Age under 12 years, individual intolerance.
Carefully:
Pregnancy and lactation, hypersensitivity.
Pregnancy and lactation:
Recommendations for FDA - Category B. Applicable with caution, in cases where the expected effect exceeds the risk to the fetus and newborn.
Dosing and Administration:Children older than 12 years - inside 1 mg each.
Adults
Inside for 1 mg, intravenously drip - 3 mg, for slow intravenous infusion - 1 mg.
The highest daily dose: 3 mg.
The highest single dose: 3 mg.
Side effects:
Central and peripheral nervous system: headache, insomnia.
Respiratory system: bronchospasm.
The cardiovascular system: arrhythmia, cardialgia, arterial hypertension.
Digestive system: gastralgia, constipation, diarrhea, flatulence, heartburn.
Dermatological reactions: a rash, swelling of the face.
Sense organs: change in taste.
Allergic reactions.
Overdose:
Cases of overdose are not described.
Treatment is symptomatic.
Interaction:
Clinically significant interactions are not described.
Special instructions:
The drug is not used in children for the purpose of preventing vomiting in the postoperative period.