Included in the formulation
АТХ:D.01.B.A.01 Griseofulvin
Pharmacodynamics:
Antibiotic with fungistatic action.Violates the division of fungal cells at the stage of metaphase. It accumulates in the cells of keratinocyte precursors, preventing fungal invasion and spread of infection.
It is active against dermatomycetes, it is ineffective in candidiasis lesions.
Pharmacokinetics:
After oral administration in the gastrointestinal tract absorbed up to 70%. The maximum concentration of the drug in the blood is reached after 4 hours.
Penetrates through the blood-brain and placental barrier, is found in breast milk. Metabolism in the liver.
The half-life is 24 hours.
It is excreted with feces.
With local application of systemic action does not render.
Indications:It is used for the treatment of dermatomycosis: favus, trichophytosis, microsporia of the scalp, inguinal epidermophyte. Used for the defeat of nails caused by pathogenic fungi: red epidermophyton, trichophyton.
I.B35-B49.B35.4 Mycosis of the trunk
I.B35-B49.B35.3 Mycosis of the feet
I.B35-B49.B35.2 Mycosis brushes
I.B35-B49.B35.1 Mycosis of nails
I.B35-B49.B35.0 Mycosis of the beard and head
I.B35-B49.B35.6 Epidermophytosis inguinal
I.B35-B49.B35.9 Dermatophytosis, unspecified
I.B35-B49.B36.8 Other specified surface fungal infections
I.B35-B49.B35 Dermatophytosis
I.B35-B49.B36.9 Superficial mycosis, unspecified
Contraindications:
Severe renal and hepatic insufficiency, porphyria, leukopenia, systemic blood diseases, malignant neoplasms, pregnancy and lactation, individual intolerance.
Carefully:
Renal and hepatic insufficiency of an average degree, hypersensitivity.
Pregnancy and lactation:
Recommendations for FDA - Category X. Contraindicated in pregnancy and lactation.
Dosing and Administration:Use in children
Children under 3 years of age are prescribed only as a suspension.
At 21-22 mg / kg per day.
With onychomycosis - 16 mg / kg per day.
Adults
Inside, with meals with 1 teaspoon of vegetable oil, 500 mg once or for 2-3 times. With microsporia, the dose increases to 1 g. Treatment continues until the first negative result of mycological analysis, after which it continues at the same dose for 2 weeks after one day, and then 2 times a week for 2 weeks.
With onychomycosis - 625 mg with a body weight of less than 50 kg. For every 10 kg of weight, 125 mg is added. The course of treatment is 8-10 months.
The highest daily dose: 2 g.
The highest single dose: 1 g.
Side effects:Central and peripheral nervous system: headache, dizziness, impaired coordination of movements, disorientation, peripheral neuropathy, confusion, rarely - hallucinations.
Hemopoietic system: leukopenia, eosinophilia, rarely - leukocytosis.
Digestive system: dry mouth, gastralgia, candidal stomatitis, hepatitis, jaundice, diarrhea.
Dermatological reactions: photosensitivity, Lyell syndrome, hives, itching.
Allergic reactions.
Overdose:
Cases of overdose are not described.
Treatment is symptomatic.
Interaction:
Reduces the concentration of cyclosporine with simultaneous application.
Special instructions:During treatment and within 6 months after taking the drug, it is recommended to use reliable methods of contraception.
During the reception of griseofulvin it is prohibited to drink alcohol.