Included in the formulation
АТХ:C.08.C Selective calcium channel blockers with a predominant effect on blood vessels
Pharmacodynamics:Diumankal - selective blocker of slow calcium channels, has antianginal, antiarrhythmic and antihypertensive effects. Due to the blockade of the slow calcium channel receptors in the smooth muscle cells of the vessels and the myocardium, the passage of calcium ions through the membranes is inhibited. As a result, coronary arteries expand, coronary blood flow increases, blood supply in the ischemia center increases, oxygen delivery to the ischemic zone increases. Diumankal reduces contractility and myocardial oxygen demand, lowers the tone of the smooth muscles of the peripheral arteries and the overall peripheral resistance of the vessels. The drug improves the rheological properties of blood, normalizing the electrolyte balance. It has antihypoxic, antioxidant action, restoring energy and protein metabolism, and also has a sedative and tocolytic effect on the body. Diumankal slows atrioventricular conduction, inhibits the automatism of the sinus node.
Pharmacokinetics:Not studied.
Indications:- Stenocardia of tension, as well as in the post-infarction period and in combination with arrhythmia.
- Chronic stable angina.
- Unstable angina.
- Angina of princemetal (vasospastic).
IX.I20-I25.I20 Angina pectoris [angina pectoris]
IX.I20-I25.I20.0 Unstable angina
IX.I20-I25.I20.1 Angina with documented spasm
Contraindications:- Hypersensitivity to the drug
- Pronounced bradycardia
- Atrioventricular blockade of II and III degree
- Sinus node weakness syndrome
- Wolff-Parkinson-White syndrome
- Chronic heart failure IIB-III stage
- Cardiogenic shock (except for arrhythmogenic)
- Acute congestive heart failure
- Simultaneous use of beta-blockers
- Pregnancy, the period of breastfeeding
- Childhood
Carefully:- Atrioventricular block of degree I
- Chronic heart failure of I and II degree
- Arterial hypotension (systolic blood pressure below 100 mm Hg)
- Severe liver function disorders
Pregnancy and lactation:Contraindicated during pregnancy. If taking the drug is vital, stop breastfeeding for the duration of treatment.
Dosing and Administration:The drug is taken orally after eating, with a small amount of water.
The initial dose for adults is 0.01 g 3 times a day for 14 days, if necessary, increase the dose to 0.02-0.03 g 3 times a day. The course of treatment is repeated after 5-7 days.
Side effects:- Allergic reactions (itching, hives)
- Dizziness, headache, drowsiness
- Bradycardia, atrioventricular block, arterial hypotension
- Nausea, vomiting, constipation
- Hyperemia of the face
- Peripheral edema
Overdose:Overdose may increase the side effects.
It should be symptomatic therapy with an overdose of the drug.
There is no specific antidote.
Interaction:Strengthening cardiotoxic effect when combined with antiarrhythmics, beta-blockers, inhalational anesthetics.
Special instructions:During treatment with the development of sedative effect, the drug can oppress the orienting reaction, therefore it is not recommended to apply it to drivers of vehicles and people whose profession is associated with increased concentration of attention and speed of psychomotor reactions.