Included in the formulation
АТХ:N.04.A.C Tropin Esters or Tropical Derivatives
Pharmacodynamics:The drug has anti-Parkinsonian, antispasmodic effect.
The peripheral action is due to the blockade of predominantly m-holinoretseptorov membranes of effector cells located in the region of the endings of postganglionic cholinergic (parasympathetic) fibers, which prevents the interaction with them of the mediator acetylcholine: relaxes smooth muscles, decreases secretion, dilates the pupil, and increases the heart rate. Antiparkinsonian activity is manifested by inhibition of central m-cholinergic structures and suppression of stimulating cholinergic effect on basal ganglia. Stronger inhibits central cholinoreactive systems and to a lesser extent affects peripheral cholinergic receptors. It also has ganglion-blocking and antispasmodic properties. Acting on the central cholinergic system, reduces motor impairment associated with the lesion of the extrapyramidal system.
Pharmacokinetics:There is no data on the pharmacokinetics of the drug.
Indications:Parkinson's disease, parkinsonism,extrapyramidal disorders (spastic paralysis, rigidity, hyperkinesis, Little disease), spasm of smooth muscles of internal organs, spastic constipation, peptic ulcer of stomach and duodenum, bronchial asthma, bradycardia caused by increased vagal tone, threat of premature birth, intoxication with organophosphorus compounds.
VI.G20-G26.G21 Secondary Parkinsonism
VI.G20-G26.G20 Parkinson's disease
X.J40-J47.J45 Asthma
XI.K20-K31.K25 Stomach ulcer
XI.K20-K31.K26 Duodenal ulcer
XIV.N20-N23.N23 Renal colic, unspecified
V.F90-F98.F90.9 Hyperkinetic disorder, unspecified
XVIII.R10-R19.R10 Pain in the abdomen and pelvis
Contraindications:Hypersensitivity, glaucoma, atrial fibrillation, ciliary tachyarrhythmia, urinary retention.
Carefully:With violations of the liver and kidneys in history.
Pregnancy and lactation:The drug is contraindicated in pregnancy and lactation.
Dosing and Administration:Inside, after meal. Adults - in a dose of 10-12.5 mg 2 times a day. With good tolerability, a single dose can be increased to 15-20 mg (in obstetrical practice appoint 20 mg twice a day).Higher doses for adults: single dose - 30 mg, daily - 100 mg. Children - 1-5 mg 1-2 times a day.
Side effects:Hyposalivation, dyspepsia, constipation, paralytic obstruction of the intestine, urinary retention, pupil dilatation, accommodation paralysis, tachycardia, headache, dizziness, general weakness, delirium, hallucinations, allergic reactions.
Overdose:Symptoms: disorders of the central nervous system (excitation, hallucinations), dry mucous membranes and skin, dilated pupils, urinary retention, tachycardia, increased intraocular pressure, increased body temperature.
Interaction:Strengthens the parasympatolytic effect of tricyclic antidepressants, violates the absorption of levodopa, shows antagonism with beta-blockers.
Special instructions:Use with caution in diseases of the liver, kidneys, heart, hypertension, severe atherosclerosis.