From the side of the central nervous system: often - dizziness (except vertigo), sleep disturbances (drowsiness or insomnia), headache (headache was less common than with placebo); sometimes - tremor, weakness, blurred vision, lethargy, anxiety, yawning; very rarely - glaucoma, mydriasis, visual impairment, agitation, disorientation.
From the digestive system: often - dry mouth, nausea, constipation; sometimes - diarrhea, vomiting, decreased appetite, change in taste, impaired liver function; very rarely - hepatitis, jaundice, increased activity of hepatic transaminases, alkaline phosphatase and bilirubin level; belching, gastroenteritis, stomatitis.
From the musculoskeletal system: sometimes - muscle tension and / or twitching; very rarely - bruxism.
From the cardiovascular system: sometimes - palpitations; very rarely - orthostatic hypotension, syncope (especially at the beginning of therapy), tachycardia, increased blood pressure, cold extremities.
On the part of the reproductive system: sometimes - anorgasmia, decreased libido, delay and violation of ejaculation, erectile dysfunction.
From the urinary system: sometimes - difficulty urinating; very rarely - nocturia.
Other: sometimes - weight loss, increased sweating, hot flashes, night sweats; very rarely anaphylactic reactions, thirst, hyponatremia, chills, angioedema, rash, Stevens-Johnson syndrome, urticaria, poor health, feeling hot and / or cold, weight gain, dehydration, photosensitivity. With cancellation, dizziness, nausea, and headache were often noted. In patients with a painful form of diabetic neuropathy, there may be a slight increase in fasting blood glucose.