Pilocarpine with methylcellulose - instructions for use, dose, side effects, contraindications

Similar drugsTo uncover

Dosage form: & nbspeye drops

Composition:

1 ml of the solution contains:

Active substance:
pilocarpine hydrochloride	10.0 mg
Excipients:
methylcellulose water-soluble	5.0 mg
sodium citrate pentasecylhydrate	4.0 mg
boric acid	10.0 mg
benzethonium chloride	0.10 mg
citric acid solution 1 M	to pH 3.5-5.5
purified water	up to 1 ml

Description:Transparent or slightly opalescent colorless or slightly colored liquid.

Pharmacotherapeutic group:antiglaucoma means - m-cholinomimetic

ATX: & nbsp

Pilocarpine

Pharmacodynamics:

Pilocarpine excites peripheral m-holinoretseptory and causes an increase secretion of digestive and bronchial glands, a sharp increase in sweating, narrowing of the pupil, an increase in the tone of smooth muscles of the bronchi, intestines, bile and bladder, uterus.

The narrowing of the pupil is accompanied by an extension of the anterior chamber angle (the iris root is drawn back), an increase in the tone of the iris and the ciliary body, as a result of which the trabecula is stretched and the blocked sections of the helmet canal are opened. Due to the widening of the anterior chamber angle and the increase in the permeability of the trabecular diaphragm, intraocular pressure decreases.

The action of pilocarpine on the level of intraocular pressure lasts for 8 hours.

Pharmacokinetics:

Pilocarpine penetrates well through the cornea, it is well absorbed through the conjunctiva. In the conjunctival sac is almost not absorbed. At the local its concentration in the aqueous humor of the eye reaches a maximum (TC_mOh) 30 minutes after instillation. It is retained in the tissues of the eye, which increases his half-life from the tissues of the eye (T_1/2), which is 1.5-2.5 hours.

Pilocarpine is not metabolized in the tissues of the eye and is excreted unchanged with intraocular fluid. Pilocarpine is transformed into an inactive form by hydrolysis in blood serum and liver. The half-life of the plasma is about 30 minutes.

Indications:

- Acute attack of angle-closure glaucoma;

- secondary glaucoma (vascular, post-traumatic (burns));

- primary open-angle glaucoma (in combination with beta-blockers or other drugs that reduce intraocular pressure);

- the need to narrow the pupil after instillation midriatikov.

Contraindications:

Hypersensitivity to the drug components, iritis, cyclit, iridocyclitis, keratitis, the condition after ophthalmic operations and other eye diseases, in which the narrowing of the pupil is undesirable, age is 18 years.

If you have any of these diseases, consult a doctor before taking the drug.

Carefully:Detachment of the retina in the anamnesis and in young patients with high degree of myopia.

If you have any of these diseases, consult a doctor before taking the drug.

Pregnancy and lactation:

Use during pregnancy is contraindicated.

If necessary, the appointment of lactation, breastfeeding should be discontinued for the duration of treatment.

Dosing and Administration:

Bury in the conjunctival sac 1-2 drops 1-3 times a day. The number of instillations can vary depending on the indications and the individual sensitivity of the patient.

For the treatment of an acute attack of angle-closure glaucoma During the first hour, pilocarpine solution is digested every 15 minutes, 2-3 hours every 30 minutes, 4-6 hours every 60 minutes, and further 3-6 times a day, until the seizure occurs.

To narrow the pupil after instillation of the mydriatic: 1 drop (or 2 drops with an interval of 5 minutes in the case of pronounced mydriasis) in each eye.

Side effects:

Systemic side effects are rare.

From the respiratory system: bronchospasm, rhinorrhea.

From the cardiovascular system: slowing of the heart rate.

From the digestive system: increased salivation.

Local reactions: pain in the eye area, myopia; impairment of twilight vision, miosis, accommodation spasm, lacrimation, superficial keratitis, allergic reactions

Other: headache (in temporal and periorbital regions)

With prolonged use: possible the development of follicular conjunctivitis, contact dermatitis eyelids.

If any of the side effects indicated in the instruction are aggravated, or you notice any other side effects not listed in the instructions, about this doctor.

Overdose:

When overdose is possible increased salivation, sweating, bradycardia, the development of bronchospasm, lowering blood pressure.

When ingestion is possible poisoning, manifested a significant increase in m-cholinomimetic effects,including with the development of severe heart failure and bronchoconstriction.

Treatment: gastric lavage; monitoring heart rate (heart rate), blood pressure (BP), respiratory function; the administration of atropine (0.5-1.0 mg subcutaneously or intravenously), epinephrine (0.3-1.0 mg subcutaneously or intramuscularly).

Interaction:

Pilocarpine hydrochloride antagonists are atropine and other m-anticholinergic agents.

With simultaneous use with adrenostimulators, antagonism of action (per pupil diameter) can be observed.

Timolol and mezaton increase the decrease in intraocular pressure, decreasing the production of intraocular fluid.

It is possible to use pilocarpine in combination with sympathomimetics, beta-adrenoblockers, inhibitors of carbonic anhydrase.

M-holinostimulating activity of pilocarpine is reduced by tricyclic antidepressants, phenothiazine derivatives, chlorprotixen, clozapine; is enhanced by anticholinesterase agents.

Possible development of bradycardia and lowering blood pressure during general anesthesia with halothane (in patients using pilocarpine in the eye drops).

Special instructions:

To reduce absorption to the systemic blood stream, it is recommended to squeeze the tear ducts after 1-2 minutes, pressing the finger at the inner corner of the eye in the area of the projection of the lacrimal sac.

Effect on the ability to drive transp. cf. and fur:

If there is an initial cataract the myotic effect can cause transient visual impairment (sensation of nearsightedness), therefore during the treatment period it is necessary to take care when driving vehicles and engage in other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions

Form release / dosage:Eye drops, 1%.

Packaging:

In bottles of 5 ml.

1 bottle with a sterile, cap-dropper and instructions for the use of the drug in a pack of cardboard.

5 bottles in a contour mesh package with foil or without foil.

1 circuit cell pack complete with 5 sterile dropper caps and instructions for the use of the drug in a pack of cardboard.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years; after opening the bottle -1 month.

Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:P N002136 / 01-2003

Date of registration:09.02.2009

The owner of the registration certificate:MOSCOW ENDOCRINE FACTORY, FSUE MOSCOW ENDOCRINE FACTORY, FSUE Russia

Manufacturer: & nbsp

MOSCOW ENDOCRINE FACTORY, FSUE Russia

Representation: & nbspMOSCOW ENDOCRINE FACTORY FGUP MOSCOW ENDOCRINE FACTORY FGUP Russia

Information update date: & nbsp20.03.2016

Illustrated instructions

Instructions

Pilocarpine with methylcellulose (PILOCARPINE WITH METHYLCELLULOSE)