Pirikarbat - instructions for use, dose, side effects, contraindications

Clinical and pharmacological group: & nbsp

Angioprotectors and microcirculation correctors

Included in the formulation

АТХ:

C.10.A.X Other lipid-lowering drugs

Pharmacodynamics:

Pharmacological action - angioprotective, improving microcirculation.

Affects the kinin-kallikreinovuyu system, mainly bradykinin. Promotes the restoration of impaired microcirculation in pathological processes, reduces the permeability of the vascular wall, prevents platelet aggregation, reduces edema of endothelial cells. Has anti-inflammatory activity, moderate hypocholesterolemic activity and promotes the reverse development of atherosclerotic changes.

In the complex therapy of pulmonary tuberculosis, the disappearance of symptoms of intoxication, resorption of infiltrates, improves the tolerability of antituberculous agents.

There is evidence of a positive effect on the stomach and pancreas in diabetes mellitus.

Pharmacokinetics:With a single administration of 500 mg, the maximum concentration(32.7 μg / ml) is achieved after 4 hours; after 48 hours it is excreted in the urine by 40%.

Indications:

Inside: atherosclerosis of the vessels of the heart, brain, limbs, IHD, cardiosclerosis, condition after a stroke, dyscirculatory encephalopathy,atherosclerotic and diabetic angiopathy, diabetic retinopathy, retinal vein thrombosis, obliterating endarteritis, trophic ulcers of the shin.

Outwardly: atopic dermatitis, diffuse neurodermatitis, radiation dermatitis (treatment and prevention).

ICD-10

VII.H30-H36.H36.0 * Diabetic retinopathy (E10-E14 + with common fourth sign .3)

VII.H30-H36.H34.8 Other retinal vascular occlusions

IX.I70-I79.I79.2 * Peripheral angiopathy in diseases classified elsewhere

IX.I70-I79.I73.8 Other specified diseases of peripheral vessels

IX.I70-I79.I73 Other peripheral vascular diseases

IX.I70-I79.I70.2 Atherosclerosis of the arteries of the extremities

IX.I60-I69.I67.2 Cerebral atherosclerosis

IX.I20-I25.I25.1 Atherosclerotic Heart Disease

XII.L55-L59.L58 Radiation dermatitis radiation

XII.L20-L30.L20 Atopic dermatitis

IX.I60-I69.I69 Effects of cerebrovascular disease

VI.G90-G99.G93.4 Encephalopathy, unspecified

IX.I20-I25.I25.9 Chronic ischemic heart disease, unspecified

Contraindications:

Hypersensitivity, impaired liver function.

Carefully:

The effectiveness and safety of the use of pyricarbate in children have not been studied.

Pregnancy and lactation:Category of recommendations FDA is not defined. Adequate and well-controlled studies in humans and animals have not been conducted.There is no information on the penetration into breast milk. Do not apply!

Dosing and Administration:

Inside

IHD, cardiosclerosis, coronary artery atherosclerosis: inside by 0.25-0.5 g 3 times a day, daily dose - 0.75-1.5 g. After the decrease or disappearance of angina attacks, the dose is reduced to 0.5-1, 0 g per day; course of treatment - 40-80 days.

Atherosclerosis of the cerebral vessels, atherosclerosis of the vessels of the lower extremities, post-stroke condition, discirculatory encephalopathy, atherosclerotic and diabetic angiopathy, diabetic retinopathy, retinal vein thrombosis, obliterating endarteritis, trophic ulcers: 1.0-1.5 g per day during 2-6 months.

Assign inside fasting for 40-60 minutes before meals to improve absorption from the gastrointestinal tract into the blood.

Outwardly.

Atopic dermatitis, diffuse neurodermatitis: apply a thin layer of ointment, lightly rubbing, 2 times a day and then apply a bandage with waxed paper.

Radiation dermatitis: ointment applied 2-3 times a day for 10-12 days. For the prevention of radiation dermatitis: apply a thin layer, lightly rubbing into the skin of the irradiation fields for 30 minutes before the session.

Side effects:

From the side cardiovascular system and blood (hematopoiesis, hemostasis): tachycardia, palpitation.

From the side GIT: rarely - nausea, gastralgia, impaired liver function (including increased activity of liver transaminases), hepatitis-like reaction (extremely rare).

Other: headache, mild ailment, skin allergic reactions.

Overdose:

Not described. Treatment is symptomatic.

Interaction:

A combination with vitamins, enzymes, coenzymes is advisable, with diabetic angiopathy - with hypoglycemic agents. With simultaneous administration with lipoic acid, there was a marked tendency to normalize lipid metabolism in chronic ischemic heart disease.

Special instructions:

For prolonged oral administration, liver function should be monitored regularly. With the development of allergic reactions in all cases, the ointment is canceled.

Instructions

Pirikarbat (Pyricarbatum)