The most frequently manifested by the gastrointestinal tract and digestive organs: pain in the epigastric region, belching, nausea, decreased appetite, vomiting, constipation or diarrhea, flatulence, erosive ulcerative lesions of the gastrointestinal tract, bleeding in the gastrointestinal tract, which in exceptional cases may cause anemia, perforation of the organs of the gastrointestinal tract; dry mouth, stomatitis.
From the hepatobiliary system: impaired liver function, increased activity of "liver" transaminases; an increase in the concentration of nitrogen and creatinine in the plasma.
From the urinary system: renal dysfunction, interstitial nephritis, papillary necrosis, nephrotic syndrome, erythrocyturia, proteinuria, hyper- or hypokalemia, glomerulonephritis, nephrosis.
From the central nervous system: dizziness, headache, tinnitus, drowsiness, insomnia, less often - depression, irritability, hallucinations, paresthesia, inhibition, mood change.
From the hemopoietic system and hemostasis: anemia, including aplastic and hemolytic, decreased hemoglobin, reduced hematocrit; leukopenia, eosinophilia, rarely - thrombocytopenia, bleeding, thrombocytopenic purpura (Henoch's disease); suppression of bone marrow function.
From the cardiovascular system: increase or decrease in blood pressure, signs of heart failure, rarely - palpitation, dyspnea.
Allergic reactions: skin rash, pruritus, erythema reaction, photosensitivity, Lyell syndrome, facial swelling, larynx, bronchospasm, malignant erythema multiforme (Stevens-Johnson syndrome), anaphylactic shock, vasculitis, serum sickness.
Other: visual impairment, edema of the shins and feet, increased sweating, increased urea concentration; increase or decrease in body weight.
The frequency of the above disorders increases with an increase in the daily dose of the drug.