Platyphylline with papaverine (Platyphylline and papaverine)

Diseases of the cardiovascular system, in which an increase in the number heartbeats may be undesirable: atrial fibrillation, tachycardia, chronic heart failure, ischemic heart disease, mitral stenosis, arterial hypertension, acute bleeding; thyrotoxicosis (tachycardia may be worse); increased body temperature (may still increase due to suppression of activity of sweat glands); reflux esophagitis, hiatal hernia, combined with reflux esophagitis (decreased esophageal and gastric motility and relaxation of the lower esophageal sphincter can contribute to slowing down gastric emptying and enhancing gastroesophageal reflux through a sphincter with impaired function); diseases of the gastrointestinal tract, accompanied by obstruction: achalasia and stenosis of the pylorus (there may be a decrease in motor and tone, leading to to obstruction and retention of stomach contents); intestinal atony in elderly patients or weakened patients (possible the development of obstruction), paralytic ileus (possible the development of obstruction); diseases with increased intraocular pressure: open angle glaucoma (mydriatic effect may cause some increase in intraocular pressure, correction of therapy may be required), age over 40 (risk of undiagnosed glaucoma); nonspecific ulcerative colitis (high doses can inhibit intestinal peristalsis, increasing the probability of paralytic intestinal obstruction, in addition, the manifestation or exacerbation of such a severe complications like toxic megacolon); dryness of the mucosa of the oral cavity (long-term use may cause further intensification of xerostomia); hepatic insufficiency (decreased metabolism) and renal insufficiency (risk development of side effects due to reduced excretion); chronic lung diseases, especially in young children and weakened patients (a decrease in bronchial secretion can lead to a thickening of the secretion and formation of congestion in the bronchi); myasthenia gravis (condition may worsen because of inhibition of the action of acetylcholine); vegetative (autonomous) neuropathy (urinary retention and paralysis of accommodation may be amplified), hypertrophy of the prostate without obstruction of the urinary tract, retention of urine or predisposition to it or disease, accompanied by obstruction of the urinary tract (including the neck of the urinary tract bladder due to prostatic hypertrophy); gestosis (possibly increased arterial hypertension); brain damage in children (effects with the sides of the central nervous system may be strengthened); Down's disease (possibly an unusual dilatation of the pupils and an increase in the number of cardiac abbreviations); central paralysis in children (reaction to anticholinergic medicines may be most pronounced); pregnancy, period rOre feeding.