Methods of application Polyoxidonium: parenteral, intranasal. The methods of application are chosen by the doctor depending on the severity of the disease and the age of the patient.
Intramuscularly or intravenously (drip): the drug is prescribed to adults in doses of 6-12 mg once a day, every other day, or 1-2 times a week, depending on the diagnosis and severity of the disease.
For intramuscular injection, the contents of the ampoule or vial are dissolved in 1.5-2 ml 0.9 % solution of sodium chloride or water for injection. For intravenous (drop), the drug is dissolved, in 2 ml of 0.9% solution of sodium chloride, Hemodesa-H, Reopoliglyukin or 5 % dextrose solution, then sterilely transferred to a vial with the indicated solutions in a volume of 200-400 ml.
The prepared solution for parenteral administration is not subject to storage. Intranasally: a dose of 6 mg is dissolved in 1 ml (20 drops) of distilled water, 0.9% sodium chloride solution or boiled water at room temperature.
Recommended treatment regimens for adults
Parenteral:
In acute inflammatory diseases: 6 mg daily for 3 days, then every other day with a total course of 5-10 injections.
When chronic inflammatory diseases: 6 mg every other day 5 injections, then 2 times a week with at least 10 injections.
With tuberculosis: 6-12 mg twice a week with a course of 10-20 injections.
In patients with acute and chronic urogenital diseases: 6 mg every other day with a course of 10 injections in combination with chemotherapy.
With chronic recurrent herpes: 6 mg every other day with a course of 10 injections in combination with antiviral drugs, interferons and / or inducers of interferon synthesis.
For the treatment of complicated forms of allergic diseases: 6 mg, 5 injections: two first injections daily, then every other day. In acute allergic and toxic-allergic conditions, administer intravenously for 6-12 mg in combination with antiallergic drugs.
With rheumatoid arthritis: 6 mg every other day 5 injections, then 2 times a week with at least 10 injections.
In cancer patients:
- before and against the background of chemotherapy to reduce immunosuppressive,hepato- and nephrotoxic action of chemotherapeutic agents for 6-12 mg every other day with a course of at least 10 injections; further the frequency of administration is determined by the doctor, depending on the tolerability and duration of chemotherapy and radiation therapy;
- for the prevention of immunosuppressive effects of the tumor, for the correction of immunodeficiency after chemotherapy and radiotherapy, after a surgical removal of the tumor, a long-term use of the preparation Polyoxidonium® (2-3 months to 1 year) for 6-12 mg 1-2 times a week is shown.
In patients with acute kidney failure is prescribed not more than 2 times a week.
Intranasal prescribe at 6 mg per day for the treatment of acute and chronic infections of the ENT organs, to strengthen the regenerative processes of the mucous membranes, to prevent complications and relapses of diseases, for the prevention of influenza and acute respiratory infections.
3 drops in each nasal passage in 2-3 hours (3 times a day) for 5-10 days.
METHODS OF USE AND DOSES FOR CHILDREN
Methods of using the preparation Polyoxidonium®: parenterally, intranasally, sublingually. The methods of application are chosen by the doctor depending on the diagnosis, severity of the disease, age and body weight of the patient.
Parenteral drug prescribed for children from 6 months in a dose of 3 mg (intramuscular or intravenously drip 0,1-0,15 mg / kg) daily, every other day or twice a week with a course of 5-10 injections (the dose calculation is indicated in the table).
For intramuscular The drug is dissolved in 1 ml of water for injection or 0.9% solution of sodium chloride.
For intravenous drip the drug is dissolved in. 1.5-2 ml sterile 0.9 % solution of sodium chloride, rheopolyglucin, Hemodesa-H or 5 % solution of dextrose, sterilely transferred into a vial with the indicated solutions in a volume of 150-250 ml.
Intranasal and sublingual: daily at a daily dose of 0.15 mg / kg for 5-10 days. The drug is administered 1-3 drops in one nasal passage or under the tongue after 2-3 hours.
For solution preparation for intranasal and sublingual The dose of 3 mg is dissolved in 1 ml (20 drops), a dose of 6 mg in 2 ml of distilled water, 0.9% sodium chloride solution or boiled water at room temperature. In one drop of the prepared solution (50 μl) contains 0.15 mg of Polyoxidonium®, which is prescribed for 1 kg of the body weight of the child.
The solution for sublingual and intranasal use should not be stored in the refrigerator for more than 7 days.Before use, the pipette with the solution should be heated to room temperature (20-25 0 FROM).
Recommended treatment regimens for children
- In acute inflammatory diseases: 0.1 mg / kg every other day with a course of 5-7 injections.
- In chronic inflammatory diseases: 0.15 mg / kg 2 times a week, with up to 10 injections.
- In acute allergic and toxic-allergic conditions: intravenously drip in a dose of 0.15 mg / kg in combination with antiallergic drugs.
- For the treatment of complicated forms of allergic diseases in combination with basic therapy: intramuscularly at 0.1 mg / kg with a course of 5 injections with an interval of 1-2 days.
Intranasal injection of 1-3 drops in one nasal passage in 2-3 hours (2-4 times a day). For intranasal and sublingual administration, the calculation of the daily dose for children is presented in the table.
| Weight of child | Number of drops per day | Volume of injected solution in ml |
| 5 kg | 5 drops | 0.25 ml |
| 10 kg | 10 drops | 0.5 ml |
| 15 kg | 15 drops | 0.75 ml |
| 20 kg | 20 drops | 1.00 ml |
Sublingually: for all indications - daily at a daily dose of 0.15 mg / kg for 10 days, for the treatment of intestinal dysbiosis for 10-20 days. Drip 1-3 drops under the tongue in 2-3 hours.