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Dosage form: & nbsplyophilizate for solution for injection
Composition:

Active substances: polyriboadenyl acid potassium salt (potassium polyriboadenylate) 0.1 mg, polyribouridic acid potassium salt (potassium polyribouridilate) 0.107 mg;

Excipients: sodium hydrogen phosphate (sodium phosphate 2-substituted) 2.0 mg, potassium dihydrogen phosphate (potassium phosphate 1-substituted anhydrous) 0.408 mg, sodium chloride 8.5 mg.

Description:Liofilizate white.
Pharmacotherapeutic group:immunostimulating agent
ATX: & nbsp
  • Antiviral drugs
  • Pharmacodynamics:

    Poludan® is a biosynthetic polyribonucleotide complex of polyriboadenyl and polyribouridyl acids. Inductor synthesis of endogenous interferon and other cytokines. Has a pronounced antiviral and immunomodulating activity. Increases the activity of natural killer cells, initially lowered in patients with ophthalmoherpes, as well as other immunocompetent cells.

    Injection administration stimulates the production of endogenous interferon in the serum and tear fluid, which is determined 3 hours after the administration. A high level of interferon (110 U / ml in the blood and 75 U / ml in the lacrimal fluid) is maintained by daily administrations throughout the wholecourse. On the second day after discontinuation of administration is practically not determined (the titer does not exceed 10 U / ml).

    Indications:

    Assign adults and children with viral eye diseases: adenovirus and herpetic keratoconjunctivitis, keratitis and keratoiridocyclitis (keratouveitis), stromal keratitis, iridocyclitis, chorioretinitis, neuritis of the optic nerve.

    Contraindications:

    Hypersensitivity to the components of the drug.

    The introduction of poludan® into the anterior chamber of the eye is contraindicated in keratoiridocyclitis with ulceration of the anterior surface of the cornea; conjunctivitis, in the presence of pathogenic microflora in planting with conjunctiva, infection of teeth and paranasal sinuses.

    Dosing and Administration:

    Subconjunctival.

    Dissolve the contents of the vial in 1 ml of water for injection or in 1 ml of 0.5% solution of novocaine and inject 0.5 ml of the conjunctiva daily or every other day. The course of treatment is 5-20 injections.

    Children

    Dissolve the contents of the vial in 1 ml of water for injection and inject under the conjunctiva to 0.25 ml every other day. The course of treatment is 8-10 injections.

    With endothelial forms of herpetic keratoiridocyclitis, under conditions of an operating: dissolve the contents of the vial of Poludan® in 1 ml of water for injection and slowly enter the anterior chamber of the eye with a tubulin syringe in a volume of 0.3-0.6 ml, 2 times a week. The course of treatment is 3 to 5 injections.

    In herpetic lesions of the posterior parts of the eye - chorioretinitis, uevita, neuritis optic nervea: dissolve the contents of the vial in 1 ml water for injections or in 1 ml of 0.5% solution of novocaine and injected periocularly (parabulbar, retrobulbarno) 1 ml every other day. The course of treatment is 10-20 injections.

    When fresh rashes shingles on the skin of a person accompanying herpetic keratitis: the contents of two flasks of Poludan® are dissolved in 10-20 ml of 0.5% solution of novocaine and injected subcutaneously along the course of herpetic rashes, every other day. These splinters, conducted every other day, effectively contribute to the removal of the pain syndrome and the reverse development of the rash. The course of treatment is 3-6 injections.

    Injectable administration of the drug is prescribed by the doctor in the absence of the effect of eye drops for 7 days.

    Side effects:

    Allergic reactions are possible.

    Subconjunctival administration causes a slight swelling of the lower eyelid and an increase in conjunctival injection of the vessels of the eye.

    When inserted into the anterior chamber of the eye, a brief increase in intraocular pressure may occur, the appearance of hemorrhages in the anterior chamber of the eye.

    Interaction:

    With the simultaneous use of Poludan® with enzyme preparations due to the destructive action of enzymes on endogenous interferon, the clinical efficacy of Poludan® decreases.

    Compatible with antibiotics and medicines for the treatment of viral infections.
    Special instructions:

    Adverse events are transient in nature and disappear after discontinuation of the drug after 1 to 3 days.

    Form release / dosage:

    Lyophilizate for solution for injection, 100 units.

    Packaging:

    100 ED in ampoules of 1 ml or in bottles of colorless glass sealed ukuporennye.

    For 10 ampoules or vials, together with instructions for use in a pack with partitions and special cardboard sockets.

    In a pack of ampoules, a knife is inserted to open the ampoules or a scarifier ampoule.

    Storage conditions:

    In a dry, dark place at a temperature of not more than 8 ° C. Keep out of the reach of children.

    Shelf life:4 of the year.
    Do not use after the expiration date printed on the package.
    Terms of leave from pharmacies:On prescription
    Registration number:LS-002204
    Date of registration:29.02.2012 / 10.11.2014
    The owner of the registration certificate:LENS-PHARM, LLC LENS-PHARM, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp20.08.2015
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