Included in the formulation
АТХ:B.05.A.A Blood plasma preparations and plasma-substituting drugs
Pharmacodynamics:Solutions for parenteral administration. Pharmacological action - plazmozameschayuschee, detoxification, antiaggregational.
Binds and removes toxins. Reduces the viscosity of the blood.
Pharmacokinetics:Dextrose: completely metabolized, not eliminated (appearance in the urine - pathology). Biotransformation in the liver through pyruvate or lactic acid to water and carbon dioxide with the release of energy.
Povidone: elimination by the kidneys.
Indications:Shock (post-traumatic, postoperative, burn, hemorrhagic).
Intoxication in the following conditions: toxic diseases of the digestive tract (shigellosis, dyspepsia, salmonellosis), burn, radiation and hemolytic disease, peritonitis, intestinal obstruction, thyrotoxicosis, liver disease, sepsis, pneumonia; acute myocardial infarction, toxemia of newborns, gestosis.
XVIII.R50-R69.R57.8 Other types of shock
XVIII.R50-R69.R57.1 Hypovolemic shock
Contraindications:Hypersensitivity, chronic heart failure IIb-III stage, bronchial asthma, respiratory failure.
Hemorrhagic stroke, phlebotrombosis, thromboembolism, diabetes mellitus (the drug contains dextrose); condition after a head injury;oliguria, anuria.
Carefully:With caution: chronic renal failure (oliguria, anuria).
Pregnancy and lactation:Category of recommendations for FDA is not defined. Adequate and well-controlled studies in humans and animals have not been conducted.
There is no information on the penetration into breast milk.
Dosing and Administration:The dosage regimen is individual, depending on the age and condition of the patient.
Intravenously drip through a system with a filter at a rate of 20-40 drops / min. Before administration, the solution is warmed to body temperature. The dose depends on the age of the patient and the severity of intoxication. Children - 2.5 ml / kg of body weight; the maximum single dose for infants is 50 ml, for children 2-5 years - 70 ml, for children 6-9 years - 100-150 ml, for children 10-15 years - 200 ml. For adults, the maximum dose is 400 ml. The drug is administered 1-2 times a day for 1-10 days.
Side effects:Allergic reactions of varying severity (up to the development of anaphylactic shock).
Overdose:Dextrose
Symptoms: hyperglycemia, glucosuria, hyperglycemic hyperosmolar coma, hyperhydration, disturbance of water-electrolyte balance.
Treatment: stopping the introduction of dextrose, the appointment of insulin, symptomatic therapy.
Povidone. Allergic reactions, nausea, vomiting.
Interaction:Povidone - interactions are possible due to adsorbing properties.
Dextrose - possible pharmaceutical and / or pharmacodynamic incompatibility in combination with other drugs, visual compatibility control is necessary.
Special instructions:Monitoring of blood pressure, kidney function.
Before the start of the infusion, the tightness and integrity of the package should be checked.
Povidone as a filler is contained in some preparations for parenteral administration; cases of povidone deposition in various tissues with subsequent damage and morbidity, liver damage were noted.