Included in the formulation
АТХ:R.05.D.B.18 Prenoxdiazine
Pharmacodynamics:Antitussive preparation of peripheral action. It causes a decrease in the sensitivity of the receptors of the bronchial mucosa (blocks the peripheral link of the cough reflex). As a result, impulses from them do not enter the cough center of the brain, coughing stops. Does not depress respiration, does not cause drug dependence, has local anesthetic and bronchodilator activity. In chronic bronchitis shows anti-inflammatory activity, which also contributes to a decrease in the intensity of cough.
Pharmacokinetics:Quickly absorbed from the stomach, and after 30 minutes the maximum concentration of the drug in the blood is reached. Therapeutic concentration persists for 6-8 hours. It binds to blood plasma proteins by 55-59%. It is excreted as metabolites and partly in unchanged form (30%) with bile through the intestine, to a lesser extent - through the kidneys. The half-life is 2.6 hours. The antitussive effect lasts 3-4 hours.
Indications:As an antitussive for catarrh of the upper respiratory tract, acute and chronic bronchitis, bronchopneumonia, bronchial asthma, emphysema; before bronchoscopy and bronchography (in combination with atropine).
X.J00-J06.J02.9 Acute pharyngitis, unspecified
X.J00-J06.J04 Acute laryngitis and tracheitis
X.J20-J22.J20.9 Acute bronchitis, unspecified
X.J40-J47.J42 Chronic bronchitis, unspecified
X.J40-J47.J43 Emphysema
X.J40-J47.J45.9 Asthma, unspecified
XVIII.R00-R09.R05 Cough
Contraindications:Hypersensitivitybronchial obstruction(bronchial asthma, chronic bronchitis), accompanied by the presence of viscous difficult to separateabout secretion or abundant sputum discharge (including post-operativeth period after inhalation anesthesia).
Carefully:Pregnancy, children's age.
Pregnancy and lactation:Category of recommendations FDA is not defined. The teratogenic effect in humans is not revealed. Carefully!
There is no information on the penetration into breast milk.
Dosing and Administration:Inside, not chewing (to avoid numbness of the mucous membrane of the mouth), 3-4 times a day: adults are usually prescribed 100 mg (in severe cases, 200 mg), children - depending on age and body weight, usually 25- 50 mg. When preparing for bronchoscopy: 1 hour before the test - 0.9-3.8 mg / kg, in combination with 0.5-1 mg of atropine.
Side effects:Numbness, dryness of the mucous membrane of the mouth and throat, nausea, diarrhea, allergic reactions (skin rash, angioedemaswelling).
Overdose:Not described. When taken in a dose exceeding the therapeutic dose, it is possible to develop weakness and sedation. Treatment is symptomatic.
Interaction:No data. It is not recommended combination with expectorant and mucolytic drugs.
Special instructions:Has no effect on the central nervous system, does not cause addiction and drug dependence.