The frequency of side effects is classified according to the recommendations of the World Health Organization: very often (> 1/10), often (> 1/100, <1/10), infrequently (> 1/1000, <1/100), rarely - (> 1/10000, <1/1000), very rarely (<1/10000), including individual messages; the frequency of the messages is unknown.
Blood and lymphatic system: very rarely - thrombocytopenia.
Immune system disorders: rarely - anaphylactic reaction, serum sickness.
Endocrine disorders: frequency
unknown - the violation of the secretion of antidiuretic hormone. Metabolism and eating disorders: often - decreased appetite (including anorexia).
Mental disorders: very often - insomnia (including early morning awakenings, initial and average insomnia); often - anxiety, nervousness, anxiety, stress, decreased libido (including lack of libido), sleep disorder, unusual dreams (including nightmares); infrequently depersonalization, rise
moods, euphoria, bruxism, unusual thoughts, violation of orgasm (including anorgasmia); rarely - hypomania, mania, hallucinations, psychomotor agitation, panic attacks; the frequency of the messages is unknown - suicidal thoughts and behavior (these symptoms may be a consequence of the underlying disease), confusion consciousness, violation of articulation.
From the nervous system: very often - headache; often - violation of attention, dizziness, dysgeusia, lethargy, drowsiness (including
hypersensitivity, sedation), tremor; infrequently - psychomotor
hyperactivity, dyskinesia, ataxia, imbalance, myoclonus; rarely - cramps, akathisia, bucco-glossal syndrome; the frequency of the messages is unknown - serotonin syndrome, memory impairment.
From the senses: often - blurred vision; infrequently - mydriasis; the frequency of the messages is unknown - ringing in the ears.
From the cardiovascular system: often - sensation
palpitation, atrial flutter, facial flushing (including hot flashes); infrequently - lowering blood pressure; rarely - vasculitis, vasodilation, arrhythmia.
From the respiratory system and mediastinal organs: often - yawning; infrequently - shortness of breath; rarely - pharyngitis; the frequency of the reports is unknown - pulmonary complications (inflammatory processes of various histopathology and / or fibrosis), nasal bleeding.
From the gastrointestinal tract: very often - diarrhea, nausea; often - vomiting, dyspepsia, dry mouth; infrequently - dysphagia; rarely - pain in the esophagus; the frequency of the messages is unknown
- gastrointestinal bleeding (including bleeding from the gums, vomiting with blood, the presence of blood in the stool, rectal bleeding, hemorrhagic diarrhea, melena, bleeding from the stomach ulcer).
On the part of the hepato-biliary system: the frequency of reports is unknown idiosyncratic hepatitis.
From the skin and subcutaneous tissue: often - a rash (including erythema, exfoliative rash, thermal rash, erythematous rash, follicular rash, generalized rash, macular rash, maculopapular rash, korepodobnuyu rash, papular rash, pruriginoznuyu rash, vesicular rash), urticaria, itching, sweating; infrequently - alopecia, a tendency to hematoma, cold sweat; rarely - Quincke's edema, ecchymosis, photosensitivity reaction, purpura; the frequency of the messages is unknown - multiform erythema (Stevens-Johnson syndrome or toxic epidermal necrolysis (Lyell's syndrome) may develop).
From the musculoskeletal system: often - pain in the joints; infrequently
- muscle twitching; the frequency of the messages is unknown - myalgia.
From the genitourinary system: often
- frequent urination (including pollakiuria); infrequently - dysuria; rarely - urine retention; the frequency of the messages is unknown - dysuria.
From the reproductive system and breast: often gynecological bleeding (including bleeding from the cervixdysfunctional uterine bleeding, bleeding from the genital tract, menometrorrhagia, menorrhagia, metrorrhagia, polymenorrhoea, postmenopausal bleeding, uterine bleeding, vaginal bleeding), erectile dysfunction, ejaculatory disorder (including absence of ejaculation, dysfunctional ejaculation, early ejaculation, ejaculation delay, retrograde ejaculation); infrequently - sexual dysfunction; the frequency of the messages is unknown - priapism.
General: very often fatigue (including asthenia); often - anxiety, chills, weight loss; infrequent - a malaise, a feeling disorder, a feeling of heat, a feeling of cold; the frequency of the reports is unknown - hemorrhage on the mucous membranes.
Laboratory indicators: rarely - hyponatremia; the frequency of the messages is unknown - a change in liver samples, a decrease in the activity of alkaline phosphatase.
Spontaneous post-marketing messages.
Endocrine system: hyperprolactinemia, single cases of growth retardation in children.
Nervous system: a syndrome of "cancellation" after discontinuation of the drug. Musculoskeletal system: an increased risk of fractures.
In pediatric practice: isolated cases of growth retardation and puberty in children, sexual dysfunction